Anti-Nogo Anticorps (A283222)

$420

Anticorps polyclonal de lapin contre Nogo pour WB et IHC-P.

Frais de livraison
Date de livraison
Livraison sous 4-6 jours ouvrables.
Téléphone
+1 (314) 370-6046
Lun - Ven, 8h - 16h AST
E-mail
orders@antibodies.com
Nom du produit
Anti-Nogo Antibody
Description du produit
Rabbit polyclonal antibody to Nogo.
Spécificité
This antibody recognises human Reticulon-4 (RTN4), also known as NogoA, neurite outgrowth inhibitor, Foocen, Neuroendocrine-specific protein, Neuroendocrine-specific protein C homolog, Reticulon-5 or RTN-x. NogoA is a 1192 amino acid multi pass transmembrane protein associated with the endoplasmic reticulum, a member of a family of integral membrane proteins termed reticulons. Six isoforms of NogoA can be generated by alternative splicing, the canonical isoform 1 is predominantly expressed in the brain and testis with weaker expression in the heart and skeletal muscle.Reticulons are involved in various neurodegenerative diseases such as Amyotrophic lateral sclerosis,and multiple sclerosis (Chiurchiù et al. 2014). Reticulon proteins have been demonstrated to regulate many cellular processes and interact with multiple proteins and receptors such as BACE. NogoA was initially identified as a myelin-associated neurite outgrowth inhibitor (Niederöst et al. 2002). NogoA is highly expressed in oligodendrocytes in the white matter of the CNS. Blocking NogoA activity with antibodies or other factors results in improved long distance axonal regeneration and functional recovery in experimental CNS lesion models (Schwab 2004).NOGOA has a predicted molecular weight of 130 kDa however, despite its predicted molecular weight, NogoA typically migrates at ~180 kDa in an SDS-PAGE. Rabbit anti human NOGOA antibody is expected to recognize all isoforms of NogoA.
Applications
WB, IHC-P
Recommander des dilutions
IHC-P: 2.5 µg/ml, WB: 0.5 - 1 µg/ml
Reactivité
Human, Mouse, Rat
Immunogène
Synthetic peptide corresponding to 23 amino acids near the C-terminus of human NogoA.
Hôte
Rabbit
Clonalité
Polyclonal
Isotype
IgG
Conjuguer

Unconjugated

Concentration
1 mg/ml
Masse moléculaire
Approximately 180 kDa in Mouse Brain tissue lysate.
Forme du produit
Liquid
Formulation
Supplied in Phosphate Buffered Saline with 0.02% Sodium Azide.
Stockage
Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.
Notes générales
Rabbit anti Human NOGOA antibody recognizes human Reticulon-4 (RTN4), also known as NogoA, neurite outgrowth inhibitor, Foocen, Neuroendocrine-specific protein, Neuroendocrine-specific protein C homolog, Reticulon-5 or RTN-x. NogoA is a 1192 amino acid multi pass transmembrane protein associated with the endoplasmic reticulum, a member of a family of integral membrane proteins termed reticulons. Six isoforms of NogoA can be generated by alternative splicing, the canonical isoform 1 is predominantly expressed in the brain and testis with weaker expression in the heart and skeletal muscle.Reticulons are involved in various neurodegenerative diseases such as Amyotrophic lateral sclerosis,and multiple sclerosis (Chiurchiù et al. 2014). Reticulon proteins have been demonstrated to regulate many cellular processes and interact with multiple proteins and receptors such as BACE. NogoA was initially identified as a myelin-associated neurite outgrowth inhibitor (Niederöst et al. 2002). NogoA is highly expressed in oligodendrocytes in the white matter of the CNS (Kuhlmann et al. 2008). Blocking NogoA activity with antibodies or other factors results in improved long distance axonal regeneration and functional recovery in experimental CNS lesion models (Schwab 2004).NOGOA has a predicted molecular weight of 130 kDa however, despite its predicted molecular weight, NogoA typically migrates at ~180 kDa in an SDS-PAGE. Rabbit anti human NOGOA antibody is expected to recognize all isoforms of NogoA.
Synonymes
1110020G17Rik, AA407876, AA409940, AA960376, ASY, C130026I10Rik, Foocen, Glut4 vesicle 20 kDa protein, Human NogoA, Kiaa0886, KIAA4153, MGC116054, MGC139261, mKIAA0886, mKIAA4153, My043 protein, Nbla00271, Nbla10545, Neurite growth inhibitor 220, Neurite Growth Inhibitor 220, included, Neurite outgrowth inhibitor, Neuroendocrine-specific protein, Neuroendocrine-specific protein C homolog, NI-250, NI220/250, Nogo A, Nogo B, Nogo C, Nogo protein, NOGOC, NSP, NSP-CL, rat N, Reticulon 4, Reticulon 5, Reticulon-4, Reticulon-5, RTN X, RTN-x, Rtn4, Rtn4 reticulon 4, RTN4-A, RTN4-B1, RTN4-B2, RTN4-C, RTN4_HUMAN, Vp20
Avertissement
Ce produit est uniquement destiné à la recherche. Il n'est pas destiné à un usage diagnostique ou thérapeutique.

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