Rabbit polyclonal antibody to Neurokinin B Receptor.
Spécificité
This antibody recognises human TACR3 otherwise known as NK3 Receptor (NK3R), a 52.2 kDa multi-pass membrane protein belonging to the G-protein coupled receptor 1 family.TACR3 is a receptor for the tachykinin neuropeptide, neuromedin-k otherwise known as neurokinin B and is highly expressed in the supraoptic and paraventricular nuclei. Following binding of its ligand, NK3R activates a phosphatidylinositol-calcium second messenger system, and it is likely that these signals lead to the release of vasopressin and oxytocin into the circulation. TACR3 is involved in learning and memory. Rabbit anti Human TACR3 antibody (AHP1492) does not recognize NK1R or NK2R.
Applications
WB, IHC-P
Recommander des dilutions
IHC-P 1: 5 µg/ml, WB: 0.5 - 1 µg/ml
Reactivité
Human, Mouse
Immunogène
A peptide corresponding to 18 amino acids near the centre of human TACR3.
Hôte
Rabbit
Clonalité
Polyclonal
Isotype
IgG
Conjuguer
Unconjugated
Concentration
1 mg/ml
Masse moléculaire
Approximately 46 kDa in RAW264.7 cell lysates.
Forme du produit
Liquid
Formulation
Supplied in Phosphate Buffered Saline with 0.02% Sodium Azide.
Stockage
Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.
Notes générales
Rabbit anti Human TACR3 antibody recognizes human TACR3 otherwise known as NK3 Receptor (NK3R), a 52.2 kDa multi-pass membrane protein belonging to the G-protein coupled receptor 1 family. TACR3 is a receptor for the tachykinin neuropeptide, neuromedin-k otherwise known as neurokinin B and is highly expressed in the supraoptic and paraventricular nuclei. Following binding of its ligand, NK3R activates a phosphatidylinositol-calcium second messenger system, and it is likely that these signals lead to the release of vasopressin and oxytocin into the circulation. TACR3 is involved in learning and memory (Zhang et al. 2020).Rabbit anti Human TACR3 antibody ( AHP1492) does not recognize NK1R or NK2R.
