Anti-NCR1 Anticorps [AKS1] (A279672)

Anti-NCR1 Antibody [AKS1] - BSA and Azide free

Mouse monoclonal [AKS1] antibody to NCR1.

This antibody recognises bovine CD335, also known as NKp46 and Natural cytotoxicity triggering receptor 1. CD335 is a type I transmembrane protein, with two extracellular C2-type immunoglobulin-like domains, which functions as an activating receptor. CD335 is expressed by human natural killer cells. The bovine homologue is expressed on bovine NK cells and no expression of CD335 has been detected on B cells, T cells, monocytes or granulocytes.Clone AKS1 is reported to activate lysis of FcgammaR-expressing cell line P815, by IL-2 activated NKp46+ cells.

WB, Flow Cytometry, Functional Assays, IF

Flow Cytometry: 1:50 - 1:200, Use 10µl of the suggested working dilution to label 10⁶ cells in 100µl

Bovine, American Bison

Fusion protein consisting of the extracellular region of bovine CD335.

Mouse

Monoclonal

AKS1

IgG1

Unconjugated

1 mg/ml

Liquid

Supplied in Phosphate Buffered Saline.

Store undiluted at -20°C only. Storage in frost free freezers is not recommended. Avoid freeze-thaw cycles. Should this product contain a precipitate we recommend microcentrifugation before use.

Mouse anti Bovine CD335 antibody, clone AKS1 recognizes bovine CD335, also known as NKp46 and Natural cytotoxicity triggering receptor 1. CD335 is a type I transmembrane protein, with two extracellular C2-type immunoglobulin-like domains, which functions as an activating receptor. CD335 is expressed by human natural killer cells (Sivori et al. 1997). The bovine homologue is expressed on bovine NK cells (Storset et al. 2004) and no expression of CD335 has been detected on B cells, T cells, monocytes or granulocytes.Clone AKS1 is reported to activate lysis of FcgammaR-expressing cell line P815, by IL-2 activated NKp46+ cells (Storset et al. 2004).

Activating NK receptor NK p46, CD335, FLJ99094, hNKp46, Ly94, Lymphocyte antigen 94, Lymphocyte antigen 94 homolog, Lymphocyte antigen 94 homolog (activating NK receptor; NK p46), Natural cytotoxicity triggering receptor 1, Natural killer cell p46-related protein, NCT1, NCTR1_HUMAN, NK cell activating receptor, NK cell-activating receptor, NK-p46, NKp46