This antibody binds an epitope in the Neural Cell Adhesion Module exons 11-13, which is dependent on an intact conformation of the first fibronectin type-III homologous domain encoded by these exons. It also reacts with a number of non-small cell lung carcinomas and neuroendocrine and neuronal derived tissues. NCAM is present in small cell lung cancer and lung carcinoids. In addition, 123C3 is internalized after binding to its antigen on SCLC cell lines, making it an excellent reagent for tumor imaging in xenograft models.
Applications
ICC, IHC-Fr, IHC-P, WB
Reactivity
Human, Zebrafish
Immunogen
The a membrane preparation of a small cell lung carcinoma specimen.
Host
Mouse
Clonality
Monoclonal
Clone ID
123C3
Isotype
IgG1
Conjugate
Unconjugated
Concentration
1 mg/ml
Product Form
Liquid
Formulation
Supplied in Phosphate Buffered Saline with 0.09% Sodium Azide.
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze/thaw cycles.