Mouse monoclonal [PCRP-NR3C2-1E3] antibody to Mineralocorticoid Receptor.
Spécificité
Mineralocorticoid hormones are primarily found in epithelial tissues where they function as regulators of Na+, K+ and H+ ion transport. Aldosterone is a mineralocorticoid that has been shown to regulate electrolyte excretion and intravascular volume and is therefore involved in blood pressure regulation. Mineralocorticoid receptor (MCR or MR) is a member of the steroid/thyroid/ retinoic nuclear hormone receptor superfamily that has been shown to activate gene transcription in response to aldosterone binding. Regulation of the mineralocorticoid receptors occurs through either receptor downregulation (negative autoregulation) or hormone-mediated upregulation (positive autoregulation). MCR association with HSP 90 appears to be required for hormone binding to MCR and subsequent MCR activation.
Applications
Flow Cytometry
Contrôle positif
HeLa cells.
Recommander des dilutions
Flow Cytometry: 1-2 µg/million cells
Reactivité
Human
Immunogène
Recombinant fragment (around Amino Acids 601-673) of human NR3C2 protein.
Hôte
Mouse
Clonalité
Monoclonal
Clone
PCRP-NR3C2-1E3
Isotype
IgG1
Conjuguer
Unconjugated
Purification
Protein A/G chromatography.
Concentration
200 µg/ml
Masse moléculaire
107 kDa
Forme du produit
Liquid
Formulation
Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.
Stockage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Synonymes
Aldosterone receptor, MCR, MCR_HUMAN, MGC133092, MLR, MR, NR3 C2, NR3C2, NR3C2 protein, Nuclear receptor subfamily 3 group C member 2
