Anti-Mineralocorticoid Receptor Antibody [NR3C2/4900] - BSA and Azide free
Description du produit
Recombinant mouse monoclonal [NR3C2/4900] antibody to Mineralocorticoid Receptor.
Spécificité
Mineralocorticoid hormones are primarily found in epithelial tissues where they function as regulators of Na+, K+ and H+ ion transport. Aldosterone is a mineralocorticoid that has been shown to regulate electrolyte excretion and intravascular volume and is therefore involved in blood pressure regulation. Mineralocorticoid receptor (MCR or MR) is a member of the steroid/thyroid/ retinoic nuclear hormone receptor superfamily that has been shown to activate gene transcription in response to aldosterone binding. Regulation of the mineralocorticoid receptors occurs through either receptor downregulation (negative autoregulation) or hormone-mediated upregulation (positive autoregulation). MCR association with HSP 90 appears to be required for hormone binding to MCR and subsequent MCR activation.
Applications
IHC-P
Contrôle positif
HeLa cells. Human kidney.
Recommander des dilutions
IHC: 1-2 µg/ml
Reactivité
Human
Immunogène
Recombinant fragment (around Amino Acids 601-673) of human NR3C2 protein.
Hôte
Mouse
Clonalité
Monoclonal
Clone
NR3C2/4900
Isotype
IgG1
Chaînes légères
kappa
Conjuguer
Unconjugated
Purification
Protein A/G chromatography.
Concentration
1 mg/ml
Masse moléculaire
107 kDa
Forme du produit
Liquid
Formulation
Supplied in 10mM Phosphate Buffered Saline; without Sodium Azide and carrier free.
Stockage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Synonymes
Aldosterone receptor, MCR, MCR_HUMAN, MGC133092, MLR, MR, NR3 C2, NR3C2, NR3C2 protein, Nuclear receptor subfamily 3 group C member 2
