Anti-MICA Anticorps [MICA/4443] (A277527)

Name: Anti-MICA Antibody [MICA/4443]
Brand: Antibodies.com
SKU: A277527
Price: 525.0 USD
Availability: InStock

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$525

Anticorps monoclonal [MICA/4443] de souris contre MICA pour WB et IHC-P.

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Alternative Formats and ConjugatesAlternative Formats

Carrier Free and Preservative Free

Livraison

Frais de livraison

$40

Date de livraison

Livraison sous 4-6 jours ouvrables.

Nous ContacterContact

Téléphone

+1 (314) 370-6046

E-mail

orders@antibodies.com

Garanties

Qualité 100 % Garantie

Garantie de Correspondance des Prix

Mots clés :

Anticorps Monospécifique

Spécifications

Nom du produit

Anti-MICA Antibody [MICA/4443]

Description du produit

Mouse monoclonal [MICA/4443] antibody to MICA.

Spécificité

MICA and MICB are stress-induced antigens that are related to major histocompatibility complex (MHC) class I molecules. MICA and MICB are frequently expressed in epithelial tumors. These highly glycosylated cell surface proteins are stably expressed without conventional class I peptide ligands or association with Î²-2-microglobulin. The expression is induced on proliferating or heat shock-stressed epithelial cells. MICA and MICB are broadly recognized by intestinal epithelial V L1 Î³ L T cells expressing variable TCRs, suggesting that these antigens may play a central role in the signaling of cellular distress to evoke immune responses in the intestinal epithelium.

Applications

WB, IHC-P

Recommander des dilutions

WB: 1-2 µg/ml, IHC-P: 1-2 µg/ml

Reactivité

Human, Mouse, Rat

Immunogène

Recombinant fragment, around amino acids 1-200, of human MICA protein. The exact sequence is proprietary.

Hôte

Mouse

Clonalité

Monoclonal

Clone

MICA/4443

Isotype

IgG2b

Chaînes légères

kappa

Conjuguer

Unconjugated

Purification

Protein A/G chromatography.

Concentration

200 µg/ml

Masse moléculaire

92 kDa

Forme du produit

Liquid

Formulation

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Stockage

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Notes générales

This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-MICA Antibody [MICA/4443] - BSA and Azide free (A278115).

Synonymes

FLJ36918, FLJ60820, HLA class I antigen , MGC111087, MGC21250, MHC class I chain related gene A protein, MHC class I chain related protein A, MHC class I chain related protein A HLA B HLA C, MHC class I polypeptide related sequence A, MHC class I polypeptide-related sequence A, MHC class I related protein, MIC A , MIC-A, MICA_HUMAN, OTTHUMP00000029088, OTTHUMP00000044528, OTTHUMP00000165170, OTTHUMP00000165172, PERB11.1, Stress inducible class I homolog

Contrôles isotype

Anticorps secondaires appropriés

Avertissement

Ce produit est uniquement destiné à la recherche. Il n'est pas destiné à un usage diagnostique ou thérapeutique.

Images (3)

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Figure 1: Immunohistochemistry - Anti-MICA Antibody [MICA/4443] (A277527)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded human kidney tissue using Anti-MICA Antibody [MICA/4443].

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Figure 2: Immunohistochemistry - Anti-MICA Antibody [MICA/4443] (A277527)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded human stomach tissue using Anti-MICA Antibody [MICA/4443].

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Figure 3: Anti-MICA Antibody [MICA/4443] (A277527)

Analysis of protein array containing more than 19,000 full-length human proteins using Anti-MICA Antibody [MICA/4443]. Z-Score and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProt^TM array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If targets on HuProt^TM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target; a MAb is considered to be specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.