Anti-MerTK Anticorps [MERTK/3024] (A278119)

Anticorps monoclonal [MERTK/3024] de souris contre MerTK pour IHC-P.

Alternative Formats and ConjugatesAlternative Formats

Frais de livraison
Date de livraison
Livraison sous 4-6 jours ouvrables.
Téléphone
+1 (314) 370-6046
Lun - Ven, 8h - 16h AST
E-mail
orders@antibodies.com
Nom du produit
Anti-MerTK Antibody [MERTK/3024] - BSA and Azide free
Description du produit
Mouse monoclonal [MERTK/3024] antibody to MerTK.
Spécificité
MerTK, also called c-Mer, is a member of the Mer/Axl/Tyro3 receptor kinase family. It is a 984 residue transmembrane protein made up of one tyrosine kinase domain, two Fibronectin type-III domains and two immunoglobulinlike C2-type domains. MerTK is the mammalian ortholog of the chicken retroviral oncogene product v-Eyk. This protein plays a critical role in macrophage activation, platelet aggregation, clot stability and the efficient removal of apoptotic cells. Specifically, MerTK acts as a signaling molecule, triggering outer segment ingestion in the retinal pigment epithelium (RPE) phagocytic process. Evidence suggests that MerTK signals via interaction with phosphatidylinositol-specific phospholipase C γ2 (PI-PLC γ2). When the gene encoding for MerTK is mutated, the RPE phagocytosis pathway is disrupted and autosomal recessive retinitis pigmentosa (RP) may result, leading to degeneration of retinal photoreceptor cells.
Applications
IHC-P
Recommander des dilutions
IHC-P: 1-2 µg/ml
Reactivité
Human
Immunogène
Recombinant fragment, around amino acids 5-148, of human MerTK. The exact sequence is proprietary.
Hôte
Mouse
Clonalité
Monoclonal
Clone
MERTK/3024
Isotype
IgG2a
Conjuguer

Unconjugated

Purification
Protein A/G chromatography.
Concentration
1 mg/ml
Masse moléculaire
110 kDa
Forme du produit
Liquid
Formulation
Supplied in 10mM Phosphate Buffered Saline; without Sodium Azide and carrier free.
Stockage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Notes générales
This monoclonal antibody is also available in a different formulation with BSA and Sodium Azide - Anti-MerTK Antibody [MERTK/3024] (A277531).
Synonymes
c MER, c mer proto oncogene tyrosine kinase, c-mer, cMER, cmer protooncogene tyrosine kinase, Eyk, MER, MER receptor tyrosine kinase, MERK, MERPEN, MERTK c-mer proto-oncogene tyrosine kinase, MERTK_HUMAN, MGC133349, nmf12, Nyk, Proto oncogene tyrosine protein kinase MER, Proto oncogene tyrosine protein kinase MER precursor, Proto-oncogene c-Mer, Receptor tyrosine kinase MerTK, RP38, STK kinase, Tyrosine-protein kinase Mer
Avertissement
Ce produit est uniquement destiné à la recherche. Il n'est pas destiné à un usage diagnostique ou thérapeutique.

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