Anti-MerTK Anticorps [MERTK/3024] (A277531)

Name: Anti-MerTK Antibody [MERTK/3024]
Brand: Antibodies.com
SKU: A277531
Price: 525.0 USD
Availability: InStock

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$525

Anticorps monoclonal [MERTK/3024] de souris contre MerTK pour IHC-P.

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Alternative Formats and ConjugatesAlternative Formats

Carrier Free and Preservative Free

Livraison

Frais de livraison

$40

Date de livraison

Livraison sous 4-6 jours ouvrables.

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Téléphone

+1 (314) 370-6046

E-mail

orders@antibodies.com

Garanties

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Mots clés :

Anticorps Monospécifique

Spécifications

Nom du produit

Anti-MerTK Antibody [MERTK/3024]

Description du produit

Mouse monoclonal [MERTK/3024] antibody to MerTK.

Spécificité

MerTK, also called c-Mer, is a member of the Mer/Axl/Tyro3 receptor kinase family. It is a 984 residue transmembrane protein made up of one tyrosine kinase domain, two Fibronectin type-III domains and two immunoglobulinlike C2-type domains. MerTK is the mammalian ortholog of the chicken retroviral oncogene product v-Eyk. This protein plays a critical role in macrophage activation, platelet aggregation, clot stability and the efficient removal of apoptotic cells. Specifically, MerTK acts as a signaling molecule, triggering outer segment ingestion in the retinal pigment epithelium (RPE) phagocytic process. Evidence suggests that MerTK signals via interaction with phosphatidylinositol-specific phospholipase C Î³2 (PI-PLC Î³2). When the gene encoding for MerTK is mutated, the RPE phagocytosis pathway is disrupted and autosomal recessive retinitis pigmentosa (RP) may result, leading to degeneration of retinal photoreceptor cells.

Applications

IHC-P

Recommander des dilutions

IHC-P: 1-2 µg/ml

Reactivité

Human

Immunogène

Recombinant fragment, around amino acids 5-148, of human MerTK. The exact sequence is proprietary.

Hôte

Mouse

Clonalité

Monoclonal

Clone

MERTK/3024

Isotype

IgG2a

Conjuguer

Unconjugated

Purification

Protein A/G chromatography.

Concentration

200 µg/ml

Masse moléculaire

110 kDa

Forme du produit

Liquid

Formulation

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Stockage

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Notes générales

This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-MerTK Antibody [MERTK/3024] - BSA and Azide free (A278119).

Synonymes

c MER, c mer proto oncogene tyrosine kinase, c-mer, cMER, cmer protooncogene tyrosine kinase, Eyk, MER, MER receptor tyrosine kinase, MERK, MERPEN, MERTK c-mer proto-oncogene tyrosine kinase, MERTK_HUMAN, MGC133349, nmf12, Nyk, Proto oncogene tyrosine protein kinase MER, Proto oncogene tyrosine protein kinase MER precursor, Proto-oncogene c-Mer, Receptor tyrosine kinase MerTK, RP38, STK kinase, Tyrosine-protein kinase Mer

Contrôles isotype

Anticorps secondaires appropriés

Avertissement

Ce produit est uniquement destiné à la recherche. Il n'est pas destiné à un usage diagnostique ou thérapeutique.

Images (3)

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Figure 1: Immunohistochemistry - Anti-MerTK Antibody [MERTK/3024] (A277531)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded human colon carcinoma tissue using Anti-MerTK Antibody [MERTK/3024].

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Figure 2: Immunohistochemistry - Anti-MerTK Antibody [MERTK/3024] (A277531)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded human colon carcinoma tissue using Anti-MerTK Antibody [MERTK/3024].

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Figure 3: Anti-MerTK Antibody [MERTK/3024] (A277531)

Analysis of protein array containing more than 19,000 full-length human proteins using Anti-MerTK Antibody [MERTK/3024]. Z-Score and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProt^TM array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If targets on HuProt^TM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target; a MAb is considered to be specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.