Recombinant Anti-Mast Cell Tryptase Anticorps [rTPSAB1/1963] (A316652)

Anti-Mast Cell Tryptase Antibody [rTPSAB1/1963] - BSA and Azide free

Recombinant mouse monoclonal [rTPSAB1/1963] antibody to Mast Cell Tryptase.

Tryptases comprise a family of trypsin-like serine proteases (peptidase family S1). Tryptases are stored in mast cell secretory granules and basophils. Mast cells are connective tissue cells derived from blood-forming tissues that line arterial walls and secrete substances, which mediate inflammatory and immune responses. Tryptases are released into the extracellular environment and are resistant to all known endogenous proteinase inhibitors. This antibody reacts with mast cells distributed in skin, synovium, lung, and heart. This antibody does not bind with any other cell type. Human mast cell tryptase is considered to be an important marker of mast cell activation and is an important mediator of inflammation. Mastocytosis is a term collectively used for a group of disorders in which there is abnormal accumulation of mast cells in one or multiple organs. Anti-tryptase, combined with anti-CD2, anti-CD25, and anti-CD117, can be useful in identifying reactive mast cell hyperplasia, myelogenous neoplasms, mast cell leukemia, and mastocytosis.

IHC-P

Human skin or tonsil.

IHC: 1-2 µg/ml

Human

Recombinant human Tryptase protein fragment (around Amino Acids 100-250). The exact sequence is proprietary.

Mouse

Monoclonal

rTPSAB1/1963

kappa

Unconjugated

Protein A/G chromatography.

1 mg/ml

31-36 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline; without Sodium Azide and carrier free.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

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