This antibody recognises human tumour necrosis factor beta (TNF-beta), also known as lymphotoxin alpha (LT-alpha), an 18.6 kDa homotrimeric polypeptide secreted by activated T and B lymphocytes, which binds to the TNF receptors TNFR1, TNFR2 and HVEM (herpes virus entry mediator receptor).TNF-beta was originally isolated due to its cytotoxic effects on tumour cells, and has since been identified as a regulator of many cellular processes and a potent mediator of inflammation and immune responses against invading pathogens.

Applications

WB, ELISA

Recommander des dilutions

ELISA: 0.5 µg/ml, WB: 0.1 - 0.2 µg/ml

Reactivité

Human

Immunogène

Recombinant human TNF-beta.

Hôte

Rabbit

Clonalité

Polyclonal

Isotype

IgG

Conjuguer

Unconjugated

Concentration

1 mg/ml after reconstitution.

Forme du produit

Lyophilized

Reconstitution

Reconstitute with 0.1 ml of distilled water. For long term storage the addition of 0.09% sodium azide is recommended.

Formulation

Supplied in Phosphate Buffered Saline.

Stockage

Lyophilized: Store at -20°C. Reconstituted: Store undiluted at -20°C, avoid freeze / thaw cycles. Storage in frost free freezers is not recommended. Should this product contain a precipitate we recommend microcentrifugation before use.

Notes générales

Rabbit anti Human TNF beta antibody recognizes human tumour necrosis factor beta (TNF-beta), also known as lymphotoxin alpha (LT-alpha), an 18.6 kDa homotrimeric polypeptide secreted by activated T and B lymphocytes, which binds to the TNF receptors TNFR1, TNFR2 and HVEM (herpes virus entry mediator receptor).TNF-beta was originally isolated due to its cytotoxic effects on tumour cells, and has since been identified as a regulator of many cellular processes and a potent mediator of inflammation and immune responses against invading pathogens.

Synonymes

DIF, LT, LT alpha, LT-alpha, LTalpha, Lymphotoxin alpha, Lymphotoxin alpha (TNF superfamily, member 1), Lymphotoxin-alpha, TNF B, TNF beta, TNF superfamily member 1, TNF, lymphocyte-derived, TNF-beta, TNFB, TNFbeta, TNFB_HUMAN, TNFSF1, TNLG1E, Tumor necrosis factor beta, tumor necrosis factor ligand 1E, Tumor necrosis factor ligand superfamily member 1

Contrôles isotype

Anticorps secondaires appropriés

Avertissement

Ce produit est uniquement destiné à la recherche. Il n'est pas destiné à un usage diagnostique ou thérapeutique.