Recombinant Anti-LRP1 Anticorps [LRP1/8947R] (A316647)

$765

Anticorps monoclonal [LRP1/8947R] de lapin contre LRP1 pour IHC-P.

Alternative Formats and ConjugatesAlternative Formats

Frais de livraison
Date de livraison
Livraison sous 4-6 jours ouvrables.
Téléphone
+1 (314) 370-6046
Lun - Ven, 8h - 16h AST
E-mail
orders@antibodies.com
Nom du produit
Anti-LRP1 Antibody [LRP1/8947R] - BSA and Azide free
Description du produit
Recombinant rabbit monoclonal [LRP1/8947R] antibody to LRP1.
Spécificité
Members of the LDL receptor gene family, including LDLR (low density lipoprotein receptor), LEP1 (low density lipoprotein related protein), megalin (also designated GP330), VLDLR (very low density lipoprotein receptor) and apoER2 are characterized by a cluster of cysteine-rich class A repeats, epidermal growth factor (EGF)-like repeats, YWTD repeats and an O-linked sugar domain. LRP1, also designated LRP and -2-Macroglobulin and apoE. LRP1 is cleaved into a membrane subunit and an extracellular subunit, which remain non-covalently associated. Proper folding and trafficking of LRP1 is facilitated by the receptor-associated protein (RAP), a molecular chaperone. The uptake of all known ligands through LRP1 can be blocked by RAP, which induces a conformational change in the receptor that renders it unable to bind ligands. LRP1, which is expressed in brain, liver and lung, is also implicated in Alzheimer s disease (AD), as the human LRP gene localizes to a potential AD locus on chromosome 12.
Applications
IHC-P
Contrôle positif
Human liver, brain or lung.
Recommander des dilutions
IHC: 1-2 µg/ml
Reactivité
Human
Immunogène
Recombinant fragment of human LRP1 protein. The exact sequence is proprietary.
Hôte
Rabbit
Clonalité
Monoclonal
Clone
LRP1/8947R
Isotype
IgG
Chaînes légères
kappa
Conjuguer

Unconjugated

Purification
Protein A/G chromatography.
Concentration
1 mg/ml
Masse moléculaire
85 kDa / 515 kDa / 600 kDa
Forme du produit
Liquid
Formulation
Supplied in 10mM Phosphate Buffered Saline; without Sodium Azide and carrier free.
Stockage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Synonymes
A2MR, Alpha 2 macroglobulin receptor, alpha 2MR, Alpha-2-macroglobulin receptor, APOER, Apolipoprotein E receptor, APR, CD 91, CD91, CD91 antigen, IGFBP3R, LDL receptor related protein 1, Low density lipoprotein receptor related protein 1, Low density lipoprotein related protein 1, Low-density lipoprotein receptor-related protein 1 intracellular domain, LRP, LRP 1, LRP 515, LRP 85, LRP ICD, LRP-1, LRP-515, LRP-85, LRP1 protein, LRP1A, LRP1_HUMAN, LRP515, LRP85, LRPICD, MGC88725, Prolow density lipoprotein receptor related protein 1, TbetaR V/LRP 1/IGFBP 3 receptor, TbetaRV/LRP1/IGFBP3 receptor, TGFBR 5, TGFBR5, Type V tgf beta receptor
Avertissement
Ce produit est uniquement destiné à la recherche. Il n'est pas destiné à un usage diagnostique ou thérapeutique.

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