Recombinant Anti-LRP1 Anticorps [LRP1/8771R] (A315262)

Anti-LRP1 Antibody [LRP1/8771R]

Recombinant rabbit monoclonal [LRP1/8771R] antibody to LRP1.

Members of the LDL receptor gene family, including LDLR (low density lipoprotein receptor), LEP1 (low density lipoprotein related protein), megalin (also designated GP330), VLDLR (very low density lipoprotein receptor) and apoER2 are characterized by a cluster of cysteine-rich class A repeats, epidermal growth factor (EGF)-like repeats, YWTD repeats and an O-linked sugar domain. LRP1, also designated LRP and -2-Macroglobulin and apoE. LRP1 is cleaved into a membrane subunit and an extracellular subunit, which remain non-covalently associated. Proper folding and trafficking of LRP1 is facilitated by the receptor-associated protein (RAP), a molecular chaperone. The uptake of all known ligands through LRP1 can be blocked by RAP, which induces a conformational change in the receptor that renders it unable to bind ligands. LRP1, which is expressed in brain, liver and lung, is also implicated in Alzheimer s disease (AD), as the human LRP gene localizes to a potential AD locus on chromosome 12.

IHC-P

Human liver, brain or lung.

IHC: 1-2 µg/ml

Human

Recombinant fragment of human LRP1 protein. The exact sequence is proprietary.

Rabbit

Monoclonal

LRP1/8771R

IgG

Unconjugated

Protein A/G chromatography.

200 µg/ml

85 kDa / 515 kDa / 600 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

A2MR, Alpha 2 macroglobulin receptor, alpha 2MR, Alpha-2-macroglobulin receptor, APOER, Apolipoprotein E receptor, APR, CD 91, CD91, CD91 antigen, IGFBP3R, LDL receptor related protein 1, Low density lipoprotein receptor related protein 1, Low density lipoprotein related protein 1, Low-density lipoprotein receptor-related protein 1 intracellular domain, LRP, LRP 1, LRP 515, LRP 85, LRP ICD, LRP-1, LRP-515, LRP-85, LRP1 protein, LRP1A, LRP1_HUMAN, LRP515, LRP85, LRPICD, MGC88725, Prolow density lipoprotein receptor related protein 1, TbetaR V/LRP 1/IGFBP 3 receptor, TbetaRV/LRP1/IGFBP3 receptor, TGFBR 5, TGFBR5, Type V tgf beta receptor