Anti-Laminin gamma 1 Anticorps [LAMC1/3162] (A277871)

Name: Anti-Laminin gamma 1 Antibody [LAMC1/3162]
Brand: Antibodies.com
SKU: A277871
Price: 525.0 USD
Availability: InStock

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$525

Anticorps monoclonal [LAMC1/3162] de souris contre Laminin gamma 1 pour IHC-P.

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Alternative Formats and ConjugatesAlternative Formats

Carrier Free and Preservative Free

Livraison

Frais de livraison

$40

Date de livraison

Livraison sous 4-6 jours ouvrables.

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Téléphone

+1 (314) 370-6046

E-mail

orders@antibodies.com

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Qualité 100 % Garantie

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Mots clés :

Anticorps Monospécifique

Spécifications

Nom du produit

Anti-Laminin gamma 1 Antibody [LAMC1/3162]

Description du produit

Mouse monoclonal [LAMC1/3162] antibody to Laminin gamma 1.

Spécificité

Laminins are large hetero-trimeric, non-collagenous glycoproteins composed of alpha, beta, and gamma chains. This MAb reacts with laminin B2/1 chain of ~210kDa and does not cross-react with other basement membrane components or fibronectin. Its specificity was established by immunoprecipitation and immunofluorescence of human skeletal muscle and kidney with laminin chain-specific MAbs. Epithelial sheets in vivo are separated from the mesenchymal elements of the stroma by a thin layer of a specialized type of extracellular matrix termed the basement membrane (BM). This structure consists of individual components, some of which are ubiquitous in BMs and some are not. The ubiquitous ones comprise laminin (LN), entactin/nidogen (EN), collagen type IV (CIV), and large heparan sulfate proteoglycan (HSPG), which interact specifically with each other to form a continuous and regular BM. Alterations of BM integrity, from local discontinuities up to complete loss, are described in many types of human and animal epithelial neoplasms. This MAb stains uniformly all human and murine basement membranes.

Applications

IHC-P

Recommander des dilutions

IHC-P: 1-2 µg/ml

Reactivité

Human

Immunogène

Murine EHS laminin preparation.

Hôte

Mouse

Clonalité

Monoclonal

Clone

LAMC1/3162

Isotype

IgG1

Chaînes légères

kappa

Conjuguer

Unconjugated

Purification

Protein A/G chromatography.

Concentration

200 µg/ml

Masse moléculaire

210 kDa

Forme du produit

Liquid

Formulation

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Stockage

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Notes générales

This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-Laminin gamma 1 Antibody [LAMC1/3162] - BSA and Azide free (A278459).

Synonymes

LAMB2, lamc1, LAMC1_HUMAN, Laminin B2 chain, Laminin subunit gamma-1, Laminin, gamma 1 (formerly LAMB2), Laminin-1 subunit gamma, Laminin-10 subunit gamma, Laminin-11 subunit gamma, Laminin-2 subunit gamma, Laminin-3 subunit gamma, Laminin-4 subunit gamma, Laminin-6 subunit gamma, Laminin-7 subunit gamma, Laminin-8 subunit gamma, Laminin-9 subunit gamma, MGC87297, S-LAM gamma, S-laminin subunit gamma

Contrôles isotype

Anticorps secondaires appropriés

Avertissement

Ce produit est uniquement destiné à la recherche. Il n'est pas destiné à un usage diagnostique ou thérapeutique.

Images (2)

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Figure 1: Immunohistochemistry - Anti-Laminin gamma 1 Antibody [LAMC1/3162] (A277871)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded human kidney tissue using Anti-Laminin gamma 1 Antibody [LAMC1/3162].

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Figure 2: Anti-Laminin gamma 1 Antibody [LAMC1/3162] (A277871)

Analysis of protein array containing more than 19,000 full-length human proteins using Anti-Laminin gamma 1 Antibody [LAMC1/3162]. Z-Score and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProt^TM array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If targets on HuProt^TM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target; a MAb is considered to be specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.