Anti-Integrin alpha V Anticorps [NKI-M7] (A115664)

Anti-Integrin alpha V Antibody [NKI-M7]

Mouse monoclonal [NKI-M7] antbody to Integrin alpha V.

This anitbody detects a melanoma-associated proteoglycan (MW greater than 450-250 kDa) and a molecular complex, which under reducing conditions consists of 4 compounds of 120, 95, 29 and 25 kDa respectively. It reacts with cultured melanomas melanomas in frozen sections, and blocks fibronectin-induced chemotaxic motility and chemokinesis of melanoma cells. The antigen is strongly associated with the adhesion and cytoplasmic spreading of melanoma cells to plastic surfaces and monolayers of vascular endothelial cells. In addition to their membrane localization, the antigens are abundant in extracellular adhesion plaques deposited by cultured melanoma cells. NKI-M7 stains primary tumors heterogeneously, whereas metastases are homogeneously stained.

ELISA, Flow Cytometry, IHC-Fr, IP

Human

Cultured melanoma cells derived from a Human melanoma metastasis.

Mouse

Monoclonal

NKI-M7

IgG1

1 mg/ml

Liquid

Supplied in Phosphate Buffered Saline with 0.09% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze/thaw cycles.

Former AMF7

antigen identified by monoclonal, CD 51, CD51, DKFZp686A08142, Integrin alpha five, integrin alpha V beta 3, Integrin alpha-5, integrin alpha-V, Integrin alpha-V light chain, integrin alphaVbeta3, integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51), ITAV_HUMAN, ITGAV, MSK 8, Msk8, Vitronectin receptor subunit alpha, VNRA, VTNR