Anti-Insulin Antibody [rIRDN/8546] - BSA and Azide free
Description du produit
Recombinant mouse monoclonal [rIRDN/8546] antibody to Insulin.
Spécificité
Recognizes a polypeptide which is identified as insulin, a 51-amino acid polypeptide composed of A and B chains connected through the C-peptide. Proinsulin, which has very little biological activity, is cleaved by proteases within its cell of origin into the insulin molecule and the C-terminal basic residue. Insulin enhances membrane transport of glucose, amino acids, and certain ions. It also promotes glycogen storage, formation of triglycerides, and synthesis of proteins and nucleic acids. Deficiency of insulin results in diabetes mellitus. The main storage site for insulin is the pancreatic islets. Antibodies to insulin are important as beta-cell and insulinoma marker.
Applications
IHC-P
Contrôle positif
MIA PaCa-2 cells. Pancreas tissue.
Recommander des dilutions
IHC: 0.1-0.2 µg/ml
Reactivité
Human
Immunogène
Recombinant full-length human Insulin protein.
Hôte
Mouse
Clonalité
Monoclonal
Clone
rIRDN/8546
Isotype
IgG2a
Chaînes légères
kappa
Conjuguer
Unconjugated
Purification
Protein A/G chromatography.
Concentration
1 mg/ml
Masse moléculaire
6 kDa
Forme du produit
Liquid
Formulation
Supplied in 10mM Phosphate Buffered Saline; without Sodium Azide and carrier free.
Stockage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Synonymes
IDDM, IDDM1, IDDM2, ILPR, ins, Insulin A chain, Insulin B chain, INS_HUMAN, IRDN, MODY10, Preproinsulin, Proinsulin, Proinsulin precursor