Anti-IL-7 Anticorps [IL7/4269] (A315182)

Anti-IL-7 Antibody [IL7/4269]

Mouse monoclonal [IL7/4269] antibody to IL-7.

Interleukin-7 (IL-7) was originally described as a factor capable of inducing in vitro proliferation of pre-B cells from marrow cultures. The IL-7 gene encodes a protein 177 amino acids in length. IL-7 exerts its biological function through the IL-7 receptor which is expressed on pre-B cells, thymocytes and bone marrow-derived macrophages. The IL-7 receptor is composed of an IL-7 receptor specific chain and the IL-2 receptor chain common to the IL-2, IL-4, IL-7, IL-9 and IL-15 receptors. IL-7 stimulation leads to the activation of Janus tyrosine kinase family members JAK1 and JAK3. Other studies have shown that in T cells, the IL-7 receptor-specific chain associates with the Src kinases family Lck and Fyn. IL-7 induces phosphorylation of Insulin receptor substrate-1 (IRS-1) and Insulin receptor substrate-2 (IRS-2), originally called 4PS.

IHC-P

Human thymus or tonsil tissue.

IHC: 1-2 µg/ml

Human

Recombinant fragment (around Amino Acids 27-177) corresponding to mature protein of human IL7. The exact sequence is proprietary.

Mouse

Monoclonal

IgG2

kappa

Unconjugated

Protein A/G chromatography.

200 µg/ml

25 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

IL 7, IL7, IL7 nirs variant 6, IL7_HUMAN, Interleukin 7, Interleukin-7, Interleukin7, LP-1, Lymphopoietin 1