Anti-IL-7 Anticorps [2D8-24-25] (A279208)

Anti-IL-7 Antibody [2D8-24-25] - BSA and Azide free

Mouse monoclonal [2D8-24-25] antibody to IL-7.

This antibody recognises interleukin-7 (IL-7) a cytokine that plays roles in the early development of B and T cells. It is also required by mature T cells for survival, proliferation and many effector functions during infection and tumor infiltration. IL-7 elicits its biological functions through IL-7 receptor a. Upon ligand binding to IL-7 receptor a, the JAK and STAT signaling pathways are activated to subsequently activate downstream signaling pathways to initiate target gene transcription (Kittipatarin & Khaled 2007, Nguyen et al. 2017). IL-7 is mainly produced by stromal cells in the bone marrow and thymus under steady states. However, IL-7 is also present at low levels in the small intestine, lungs, liver and skin where it can modulate T cell responses.

WB, ELISA

ELISA: 1 µg/ml - 2.0 µg/ml, WB: 0.25 µg/ml - 0.5 µg/ml

Human

E. coli derived recombinant human interleukin-7.

Mouse

Monoclonal

2D8-24-25

IgG1

Unconjugated

1 mg/ml after reconstitution.

Lyophilized

Reconstitute with 0.5 ml of distilled water.

Supplied in Phosphate Buffered Saline.

Lyophilized: Store at -20°C. Reconstituted: Store undiluted at -20°C, avoid freeze / thaw cycles. Storage in frost free freezers is not recommended. Should this product contain a precipitate we recommend microcentrifugation before use.

Mouse anti Human interleukin-7 antibody, clone 2D8-24-25, recognizes interleukin-7 (IL-7) a cytokine that plays roles in the early development of B and T cells. It is also required by mature T cells for survival, proliferation and many effector functions during infection and tumor infiltration (Sheikh & Abraham 2019). IL-7 elicits its biological functions through IL-7 receptor a. Upon ligand binding to IL-7 receptor a, the JAK and STAT signaling pathways are activated to subsequently activate downstream signaling pathways to initiate target gene transcription (Kittipatarin & Khaled 2007, Nguyen et al. 2017). IL-7 is mainly produced by stromal cells in the bone marrow and thymus under steady states. However, IL-7 is also present at low levels in the small intestine, lungs, liver and skin where it can modulate T cell responses (Sheikh & Abraham 2019).

IL 7, IL7, IL7 nirs variant 6, IL7_HUMAN, Interleukin 7, Interleukin-7, Interleukin7, LP-1, Lymphopoietin 1