Anti-IL-32 Antibody [E03-4C9] (A280288)

Anti-IL-32 Antibody [E03-4C9]

Mouse monoclonal [E03-4C9] antibody to IL-32.

This antibody recognises interleukin-32 (IL-32), also known as NK4 and TAIF. IL-32 is a pro-inflammatory cytokine with roles in inflammation and immune regulation, and its expression is strongly regulated by pathogens and pro-inflammatory cytokines. IL-32 promotes inflammation by upregulating other inflammatory cytokines including TNF-a, IL-1ß, IL-6, INF-?, and IL-8. Accordingly, a role for IL-32 has been reported in the pathogenesis of chronic inflammatory diseases including IBD, COPD and RA. IL-32 is highly expressed in several cancer tissues, and plays a crucial role in cancer development through tumor initiation, cell proliferation, and tumor maintenance. The purified Mouse anti Human interleukin-32 antibody, clone E03-4C9 (MCA6212GA) can be used as a capture antibody in a sandwich ELISA with the biotinylated Mouse anti Human interleukin-32 antibody, clone B01-2A7 (MCA6213B) as the detection antibody.

ELISA: 1 µg/ml

Human

E. coli derived recombinant human interleukin-32 (Cys2-Lys131).

Mouse

Monoclonal

E03-4C9

IgG1

1 mg/ml

Liquid

Supplied in Phosphate Buffered Saline with 0.09% Sodium Azide.

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

Mouse anti Human interleukin-32 antibody, clone E03-4C9, recognizes interleukin-32 (IL-32), also known as NK4 and TAIF. IL-32 is a pro-inflammatory cytokine with roles in inflammation and immune regulation, and its expression is strongly regulated by pathogens and pro-inflammatory cytokines (Hong et al. 2017). IL-32 promotes inflammation by upregulating other inflammatory cytokines including TNF-a, IL-1ß, IL-6, INF-?, and IL-8 (Al-Shobaili et al. 2018). Accordingly, a role for IL-32 has been reported in the pathogenesis of chronic inflammatory diseases including IBD, COPD and RA (Damen et al. 2017). IL-32 is highly expressed in several cancer tissues, and plays a crucial role in cancer development through tumor initiation, cell proliferation, and tumor maintenance (Yan et al. 2018).The purified Mouse anti Human interleukin-32 antibody, clone E03-4C9 (MCA6212GA) can be used as a capture antibody in a sandwich ELISA with the biotinylated Mouse anti Human interleukin-32 antibody, clone B01-2A7 (MCA6213B) as the detection antibody.

IL32, Interleukin-32, Natural killer cells protein 4, NK4, TAIF, Tumor necrosis factor alpha-inducing factor