This antibody recognises human IGFBP-7 (insulin-like growth factor binding protein-7), also known as mac25, a 256 amino acid secreted protein and member of a growing family of IGFBPs which regulate the biological activities and distribution of the insulin-like growth factors (IGFs), through binding to IGF-I and IGF-II.IGFBP-7 is widely expressed throughout normal tissues, but is also expressed in many tumour types at an increased or reduced level, and acts as a suppressor of breast and prostate cancer cell lines. IGFBP-7 inhibits IGF-induced differentiation of skeletal muscle (myogenesis) and has implications in bone formation, by its possible affects on the actions of parathyroid hormone (PTH) and cortisol.

Applications

WB, ELISA

Recommander des dilutions

ELISA: 0.5 - 2 µg/ml, WB: 0.1 - 0.2 µg/ml

Reactivité

Human

Immunogène

Recombinant human IGFBP-7.

Hôte

Rabbit

Clonalité

Polyclonal

Isotype

IgG

Conjuguer

Unconjugated

Concentration

1 mg/ml after reconstitution.

Forme du produit

Lyophilized

Reconstitution

Reconstitute with 0.1 ml of distilled water. For long term storage the addition of 0.09% sodium azide is recommended.

Formulation

Supplied in Phosphate Buffered Saline.

Stockage

Lyophilized: Store at -20°C. Reconstituted: Store undiluted at -20°C, avoid freeze / thaw cycles. Storage in frost free freezers is not recommended. Should this product contain a precipitate we recommend microcentrifugation before use.

Notes générales

Rabbit anti Human IGFBP-7 antibody recognizes human IGFBP-7 (insulin-like growth factor binding protein-7), also known as mac25, a 256 amino acid secreted protein and member of a growing family of IGFBPs which regulate the biological activities and distribution of the insulin-like growth factors (IGFs), through binding to IGF-I and IGF-II.IGFBP-7 is widely expressed throughout normal tissues, but is also expressed in many tumour types at an increased or reduced level, and acts as a suppressor of breast and prostate cancer cell lines. IGFBP-7 inhibits IGF-induced differentiation of skeletal muscle (myogenesis) and has implications in bone formation, by its possible affects on the actions of parathyroid hormone (PTH) and cortisol.

Synonymes

AGM, Angiomodulin, FSTL2, IBP-7, IBP7, IBP7_HUMAN, IGF binding protein 7, IGF-binding protein 7, IGFBP rP1, IGFBP-7, IGFBP-rP1, IGFBPRP1, Insulin like growth factor binding protein 7, Insulin-like growth factor-binding protein 7, MAC25, MAC25 protein, PGI2 stimulating factor, PGI2-stimulating factor, Prostacyclin stimulating factor, Prostacyclin-stimulating factor, PSF, RAMSVPS, TAF, Tumor-derived adhesion factor

Contrôles isotype

Anticorps secondaires appropriés

Avertissement

Ce produit est uniquement destiné à la recherche. Il n'est pas destiné à un usage diagnostique ou thérapeutique.