Anti-IGF1 Receptor Anticorps [IGF1R/4667] (A277659)

Anti-IGF1 Receptor Antibody [IGF1R/4667]

Mouse monoclonal [IGF1R/4667] antibody to IGF1 Receptor.

Receptor tyrosine kinases (RTKs) are transmembrane molecular scaffolds that influence cellular processes including the cell cycle, cell migration, cell metabolism, cell survival, proliferation and differentiation. Insulin-like growth factor-I receptor (IGF-IR) is an RTK that stimulates growth in many different cell types, blocks apoptosis, acts as an intermediate of many growth hormone responses and may stimulate the growth of some types of cancer. The IGF-IR cognate ligand Insulin-like growth factor-I (IGF-I) promotes association of IGF-IR with Shc, GRB2 and Sos 1, which initiates Ras and ERK kinase cascades, thereby modifying transcription factor activity, such as activation of the Elk transcription factors. The modular phosphotyrosine binding (PTB) domains of Insulin receptor substrate (IRS)-1 and -2 can associate with active IGF-IR and initiate phosphatidylinositol 3-kinase-dependent downstream signals. The human IGF-IR gene maps to chromosome 15q26.3 and encodes a 1,376 amino acid precursor protein that cleaves into α and β subunits. The human IGF-IIR gene maps to chromosome 6q26 and encodes a 2,491 amino acid transmembrane protein.

Flow Cytometry, IF

Flow Cytometry: 1-2 µg/million cells, IF: 1-4 µg/ml

Human

Recombinant fragment, around amino acids 550-750, of human IGF1 Receptor. The exact sequence is proprietary.

Mouse

Monoclonal

IGF1R/4667

kappa

Unconjugated

Protein A/G chromatography.

200 µg/ml

130 kDa (IGF-1R) / 97 kDa (IGF-1R) / 200 kDa (pro-IGF-1R)

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-IGF1 Receptor Antibody [IGF1R/4667] - BSA and Azide free (A278247).

CD221, CD221 antigen, IGF 1 receptor, IGF 1R, IGF I receptor, IGF-I receptor, Igf1r, IGF1R_HUMAN, IGFIR, IGFIRC, IGFR, Insulin like growth factor 1 receptor, Insulin like growth factor 1 receptor precursor, Insulin-like growth factor 1 receptor beta chain, Insulin-like growth factor I receptor, JTK13, MGC142170, MGC142172, MGC18216, Soluble IGF1R variant 1, Soluble IGF1R variant 2