Mouse monoclonal [GLUL/6601] antibody to Glutamine Synthetase.
Spécificité
Glutamine synthetase (Gl Syn) forms a homo-octamer that serves as a catalyst for the amination of glutamic acid to form glutamine. This enzyme is a marker for astrocytes, which serve as the primary site of conversion of glutamic acid to glutamine in the brain. Induction of glutamine synthetase is seen upon astrocyte cell contact with neurons. Elevated expression of glutamine synthetase in glial cells has been shown to protect neurons from degeneration due to excess glutamate. Glutamine synthetase is also present in the liver and is involved in nitrogen homeostasis. Overexpression of glutamine synthetase has been shown in primary liver cancers, indicating a potential role for glutamine synthetase in hepatocyte transformation.
Applications
WB, IHC-P
Contrôle positif
Human brain, stomach or thyroid. A-431 or Y79 cells.
Recommander des dilutions
WB: 1-2 µg/ml, IHC: 1-2 µg/ml
Reactivité
Human, Horse, Canine, Feline
Immunogène
Recombinant fragment (around Amino Acids 50-250) of human GLUL protein. The exact sequence is proprietary.
Hôte
Mouse
Clonalité
Monoclonal
Clone
GLUL/6601
Isotype
IgG2b
Chaînes légères
kappa
Conjuguer
Unconjugated
Purification
Protein A/G chromatography.
Concentration
200 µg/ml
Masse moléculaire
42 kDa
Forme du produit
Liquid
Formulation
Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.
Stockage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.