Anti-GBP1 Anticorps [GBP1/7618] (A316381)

$765

Anticorps monoclonal [GBP1/7618] de souris contre GBP1 pour IHC-P.

Alternative Formats and ConjugatesAlternative Formats

Frais de livraison
Date de livraison
Livraison sous 4-6 jours ouvrables.
Téléphone
+1 (314) 370-6046
Lun - Ven, 8h - 16h AST
E-mail
orders@antibodies.com
Nom du produit
Anti-GBP1 Antibody [GBP1/7618] - BSA and Azide free
Description du produit
Mouse monoclonal [GBP1/7618] antibody to GBP1.
Spécificité
GBP1 (guanylate binding protein 1) is a 592 amino acid protein member of the GTPase protein family and is able to bind specifically to guanine nucleotides such as GMP, GDP and GTP. GMP is hydrolyzed to GTP in two consecutive cleavage steps, both of which are carried out by GBP1. Localized to the cytoplasm, GBP1 is expressed in endothelial cells of the vascular system and is induced by IFN-g during macrophage induction. GBP1 is thought to regulate the expression of MMP-1, which mediates the proliferation and invasiveness of endothelial cells. GBP1 plays a key role in regulating inflammatory cytokines and provides protection against vesicular stomatitis and encephalomyocarditis viruses. GBP1 expression is highly induced in the vessels of skin diseases such as psoriasis and Kaposi s sarcoma, making it a novel cellular activation marker that characterizes inflammatory cytokines of endothelial cells.
Applications
IHC-P
Contrôle positif
Human colon or cerebral cortex tissue.
Recommander des dilutions
IHC: 1-2 µg/ml
Reactivité
Human
Immunogène
Recombinant fragment (around Amino Acids 400-592) of human GBP1 protein. The exact sequence is proprietary.
Hôte
Mouse
Clonalité
Monoclonal
Clone
GBP1/7618
Isotype
IgG
Conjuguer

Unconjugated

Purification
Protein A/G chromatography.
Concentration
1 mg/ml
Masse moléculaire
67 kDa
Forme du produit
Liquid
Formulation
Supplied in 10mM Phosphate Buffered Saline; without Sodium Azide and carrier free.
Stockage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Synonymes
GBP 1, GBP-1, GBP1_HUMAN, GTP binding protein 1, GTP-binding protein 1, Guanine nucleotide binding protein 1, Guanine nucleotide-binding protein 1, Guanylate binding protein 1, Guanylate binding protein 1 interferon inducible, Guanylate binding protein 1 interferon inducible 67kDa, HuGBP 1, HuGBP-1, HuGBP1, Interferon induced guanylate binding protein 1, Interferon-induced guanylate-binding protein 1, OTTHUMP00000012352
Contrôles isotype
Avertissement
Ce produit est uniquement destiné à la recherche. Il n'est pas destiné à un usage diagnostique ou thérapeutique.

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