FOXL1 is a 337 amino acid protein encoded by the mouse gene FOXL1. FOXL1 belongs to the forkhead family and contains one forkhead DNA-binding domain. The HNF3/forkhead family includes a large number of transcription factors that share a structurally related DNA binding domain. forkhead factors are known to play important roles both during development and in adults. FOXL1 is a winged helix transcriptional regulator expressed in the mesenchymal layer of developing and mature gastrointestinal tract. FOXL1-deficient mice exhibit various defects not only in the epithelial layer of the gastrointestinal tract but also in gut-associated lymphoid tissues. In the small intestine of FOXL1-deficient mice, the formation of Peyers patches is affected, particularly in the caudal region. FOXL1 is a mesenchymal modifier of the Adenomatous Polyposis Coli (APC) gene products and plays a key role in gastrointestinal tumorigenesis.

Applications

IP, Flow Cytometry, IF, WB, IHC-P

Contrôle positif

HeLa or U87 cells. Ubiquitous tissue expression.

Recommander des dilutions

IP: 1-2 µg per 100-500ug of total protein, Flow Cytometry: 1-2 µg/million cells, IF: 1-2 µg/ml, WB: 1-2 µg/ml, IHC: 1-2 µg/ml

Reactivité

Human

Immunogène

Recombinant fragment (around Amino Acids 104-258) of human FOXL1 protein. The exact sequence is proprietary.

Hôte

Mouse

Clonalité

Monoclonal

Clone

PCRP-FOXI1-1C4

Isotype

IgG2a

Conjuguer

Unconjugated

Purification

Protein A/G chromatography.

Concentration

200 µg/ml

Masse moléculaire

36-41 kDa

Forme du produit

Liquid

Formulation

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Stockage

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Synonymes

FKH10, FKHL10, Forkhead (Drosophila) like 10, Forkhead box I1, Forkhead box protein I1, Forkhead like 10, Forkhead related activator 6, Forkhead related transcription factor 6, Forkhead-related protein FKHL10, Forkhead-related transcription factor 6, FOXI1_HUMAN, FREAC 6, FREAC-6, FREAC6, Hepatocyte nuclear factor 3 forkhead homolog 3, HFH 3, HFH-3, HFH3, HNF 3/fork head homolog 3, HNF-3 fork-head homolog 3, HNF-3/fork-head homolog 3, Human HNF-3 fork-head homolog-3 HFH-3 mRNA complete cds, MGC34197

Contrôles isotype

Anticorps secondaires appropriés

Avertissement

Ce produit est uniquement destiné à la recherche. Il n'est pas destiné à un usage diagnostique ou thérapeutique.