Anti-FLI1 Anticorps [FLI1/7508] (A316355)

$765

Anticorps monoclonal [FLI1/7508] de souris contre FLI1 pour WB et IHC-P.

Alternative Formats and ConjugatesAlternative Formats

Frais de livraison
Date de livraison
Livraison sous 4-6 jours ouvrables.
Téléphone
+1 (314) 370-6046
Lun - Ven, 8h - 16h AST
E-mail
orders@antibodies.com
Nom du produit
Anti-FLI1 Antibody [FLI1/7508] - BSA and Azide free
Description du produit
Mouse monoclonal [FLI1/7508] antibody to FLI1.
Spécificité
Recognizes a protein of 51kDa, which is identified as FLI1. This protein, a member of the ETS family of DNA binding transcription factors, is involved in cellular proliferation and tumorigenesis. Ets-1 is the prototype member of a family of genes identified on the basis of homology to the v-Ets oncogene isolated from the E26 erythroblastosis virus. Members of the Ets gene family share a highly conserved carboxy-terminal domain containing a sequence related to the SV40 large T antigen nuclear localization signal sequence. Approximately 90% of Ewing s Sarcoma (EWS) / Primitive Neuroectodermal Tumors (PNET) have a specific translocation, t(11;22)(q24;q12), which results in fusion of EWS to Fli-1, and production of an EWS-Fli-1 fusion protein. Among normal tissues only endothelial cells and small lymphocytes express Fli-1. This protein is expressed in majority of vascular tumors including angiosarcomas, hemangioendotheliomas, hemangiomas, and Kaposi s Sarcomas. High sensitivity and specificity of Fli-1 equals to or exceeds that of the established vascular markers like CD31, CD34, and Factor VIII.
Applications
WB, IHC-P
Contrôle positif
THP1 and Raji cells. Tonsil, Ewing s sarcoma (EWS) and Angiosarcoma
Recommander des dilutions
WB: 1-2 µg/ml, IHC: 1-2 µg/ml
Reactivité
Human
Immunogène
Recombinant fragment (aa 107-261) of human FLI1 protein with hexa-histidine tag.
Hôte
Mouse
Clonalité
Monoclonal
Clone
FLI1/7508
Isotype
IgG2
Chaînes légères
kappa
Conjuguer

Unconjugated

Purification
Protein A chromatography.
Concentration
1 mg/ml
Masse moléculaire
51 kDa
Forme du produit
Liquid
Formulation
Supplied in 10mM Phosphate Buffered Saline; without Sodium Azide and carrier free.
Stockage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Synonymes
ERGB transcription factor, Ewing Sarcoma breakpoint region 2, EWSR 2, EWSR2, FLI 1, FLI 1 proto oncogene, Fli-1 proto-oncogene, ETS transcription factor, FLI1 EWS fusion gene, FLI1 proto oncogene, FLI1_HUMAN, Friend leukemia integration 1 (FLI1) transcription factor, Friend leukemia integration 1 transcription factor, Friend leukemia virus integration 1, Proto-oncogene Fli-1, Sarcoma breakpoint region 2 (EWSR2), SIC 1, SIC1, Transcription factor ERGB, Viral integration region FLI1, Viral integration region FLI1, mouse, homolog of
Avertissement
Ce produit est uniquement destiné à la recherche. Il n'est pas destiné à un usage diagnostique ou thérapeutique.

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