Anti-Eotaxin 2 Antibody [B01-5E2] (Biotin) (A279723)

Anti-Eotaxin 2 Antibody [B01-5E2] (Biotin)

Mouse monoclonal [B01-5E2] antibody to Eotaxin 2 (Biotin).

This antibody recognises C-C motif chemokine 24, also known as Eotaxin-2, CK-beta-6, and MPIF-2. CCL24 is a chemokine which is induced in macophages and promotes recruitment and activation of immune cells including eosinophils, basophils, and Th2 cells by interacting with the CCR3 receptor. Therefore, CCL24 expression increases during inflammatory disease and allergic reaction, and CCL24 has been shown to perpetuate allergic reaction. CCL24 is involved with proinflammatory and profibrotic reactions, particularly fibrosis of the skin and lungs. Furthermore, CCL24 plays a role in intrahepatic fibrosis and liver damage. Elevated CCL24 has been associated with primary colorectal and liver metastatic tumors. The biotinylated Mouse anti Human CCL24 antibody, clone B01-5E2 (MCA6183B) can be used as a detection antibody in a sandwich ELISA with the purified Mouse anti Human CCL24 antibody, clone C05-2B5 (MCA6182GA) as the capture antibody.

ELISA: 1 µg/ml

Human

E. coli derived recombinant human full length CCL24 (Val27-Ala104).

Mouse

Monoclonal

B01-5E2

IgG1

Protein G affinity chromatography of tissue culture supernatant.

100 µg/ml

Liquid

Supplied in Phosphate Buffered Saline with 1% BSA and 0.09% Sodium Azide.

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended. This product is photosensitive and should be protected from light.

Mouse anti Human CCL24 antibody, clone B01-5E2, recognizes C-C motif chemokine 24, also known as Eotaxin-2, CK-beta-6, and MPIF-2. CCL24 is a chemokine which is induced in macophages and promotes recruitment and activation of immune cells including eosinophils, basophils, and Th2 cells by interacting with the CCR3 receptor. Therefore, CCL24 expression increases during inflammatory disease and allergic reaction, and CCL24 has been shown to perpetuate allergic reaction (Cho et al. 2016). CCL24 is involved with proinflammatory and profibrotic reactions, particularly fibrosis of the skin and lungs (Mor et al. 2019). Furthermore, CCL24 plays a role in intrahepatic fibrosis and liver damage (Segal-Salto et al. 2020). Elevated CCL24 has been associated with primary colorectal and liver metastatic tumors (Cheng et al. 2017). The biotinylated Mouse anti Human CCL24 antibody, clone B01-5E2 (MCA6183B) can be used as a detection antibody in a sandwich ELISA with the purified Mouse anti Human CCL24 antibody, clone C05-2B5 (MCA6182GA) as the capture antibody.

C-C motif chemokine 24, CCL24, CK-beta-6, Eosinophil chemotactic protein 2, Eotaxin-2, MPIF-2, MPIF2, Myeloid progenitor inhibitory factor 2, SCYA24, Small-inducible cytokine A24

This product is for research use only. It is not intended for diagnostic or therapeutic use.