Anti-Cytokeratin 6 Antibody [SPM269] - BSA and Azide free (A252308)

Anti-Cytokeratin 6 Antibody [SPM269] - BSA and Azide free

Mouse monoclonal [SPM269] antibody to Cytokeratin 6.

This antibody recognizes a protein of 56kDa, identified as cytokeratin 6 (CK6). In humans, multiple isoforms of Cytokeratin 6 (6A-6F), encoded by several highly homologous genes, have distinct tissue expression patterns, and Cytokeratin 6A is the dominant form in epithelial tissue. The gene encoding human Cytokeratin 6A maps to chromosome 12q13, and mutations in this gene are linked to several inheritable hair and skin pathologies. Keratins 6 and 16 are expressed in keratinocytes, which are undergoing rapid turnover in the suprabasal region (also known as hyper-proliferation-related keratins). Keratin 6 is found in hair follicles, suprabasal cells of a variety of internal stratified epithelia, in epidermis, in both normal and hyper-proliferative situations. Epidermal injury results in activation of keratinocytes, which express CK6 and CK16. CK6 is strongly expressed in about 75% of head and neck squamous cell carcinomas. Expression of CK6 is particularly associated with differentiation.

Flow Cytometry, IF, IHC-P

Flow Cytometry: 1-2 µg/million cells, IF: 1-2 µg/ml, IHC-P: 1-2 µg/ml

Human, Mouse

Synthetic peptide corresponding to the C terminus of human Keratin 6.

GSSTIKYTTTS

Mouse

Monoclonal

SPM269

IgG2a

Protein A/G chromatography.

1 mg/ml

56 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline; without Sodium Azide and carrier free.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

This monoclonal antibody is also available in a different formulation with BSA and Sodium Azide - Anti-Cytokeratin 6 Antibody [SPM269] (A249128).

CK-6C, CK-6E, Cytokeratin-6C, Cytokeratin-6E, K6C, Keratin K6h, Keratin, type II cytoskeletal 6C, Keratin-6C, KRT6C, KRT6E, Type-II keratin Kb12