Recombinant Anti-Cytokeratin 10 Anticorps [KRT10/7804R] (A316223)

Anti-Cytokeratin 10 Antibody [KRT10/7804R] - BSA and Azide free

Recombinant rabbit monoclonal [KRT10/7804R] antibody to Cytokeratin 10.

This MAb recognizes a protein of 56.5kDa, identified as cytokeratin 10 (CK10). CK10 is expressed in all suprabasal layers of the epidermis. In the epidermis, expression of CK10 strictly parallels the extent of differentiation; it is absent in the basal layer, appears in the first suprabasal layers and increases in concentration towards the granular layer. However, CK10 is rarely detected in early stages of vulvar squamous carcinomas (tumors less than 2 cm, clinical stage I) regardless of the tumor grade. In larger and more advanced tumors (greater than 2 cm, clinical stages II and III), CK10 is detected very frequently. Expression of CK10 is related to maturation of malignant keratinocytes, being preferentially detected in more-differentiated parts.

IHC-P

Human skin.

IHC: 1-2 µg/ml

Human

Recombinant human fragment (around Amino Acids 500-600) of human KRT10 protein. The exact sequence is proprietary.

Rabbit

Monoclonal

KRT10/7804R

kappa

Unconjugated

Protein A/G chromatography.

1 mg/ml

56.5 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline; without Sodium Azide and carrier free.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

BCIE, BIE, CK 10, CK-10, Cytokeratin-10, EHK, K10, K1C10_HUMAN, Keratin, Keratin 10, Keratin 10 type I, Keratin type i cytoskeletal 10, Keratin type I cytoskeletal 59 kDa, Keratin-10, Keratin10, KPP, KRT10, type I cytoskeletal 10