Recombinant Anti-CXCR5 Antibody [CXCR5/8146R] (A314831)

Anti-CXCR5 Antibody [CXCR5/8146R]

Recombinant rabbit monoclonal [CXCR5/8146R] antibody to CXCR5.

Burkitt s lymphoma receptor 1 (Blr1) is a lymphocyte specific chemokine receptor expressed at low levels in secondary lymphoid tissues and in defined structures of the cerebellum. The G protein-coupled receptor has significant homology to other chemokine receptors. Stimulation of Blr1 by its ligand, B-lymphocyte chemoattractant (BLC) results in an influx of calcium into the cell and the chemotaxis of the cell. Blr1 is required for B-cell migration into splenic and Peyer s patch follicles. BLC expression in Peyer s patches is highest in germinal centers, where B cells undergo somatic mutation and affinity maturation.

Human tonsil or diffuse large b-lymphoma.

IHC: 1-2 µg/ml

Human

Recombinant fragment (around Amino Acids 1-200) of human CXCR5 protein. The exact sequence is proprietary.

Rabbit

Monoclonal

CXCR5/8146R

kappa

Protein A/G chromatography.

200 µg/ml

56 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

BLR1, Burkitt lymphoma receptor 1, C-X-C chemokine receptor type 5, CD185, CXC-R5, CXCR-5, MDR-15, MDR15, Monocyte-derived receptor 15