Recombinant Anti-COX2 Anticorps [COX2/7803R] (A316194)

$765

Anticorps monoclonal [COX2/7803R] de lapin contre COX2 pour IHC-P.

Alternative Formats and ConjugatesAlternative Formats

Frais de livraison
Date de livraison
Livraison sous 4-6 jours ouvrables.
Téléphone
+1 (314) 370-6046
Lun - Ven, 8h - 16h AST
E-mail
orders@antibodies.com
Nom du produit
Anti-COX2 Antibody [COX2/7803R] - BSA and Azide free
Description du produit
Recombinant rabbit monoclonal [COX2/7803R] antibody to COX2.
Spécificité
Prostaglandins are a diverse group of autocrine and paracrine hormones that mediate many cellular and physiologic processes. Prostaglandin H2 (PGH2) is an intermediate molecule in formation of the prostaglandins. Cyclooxygenase-1 (Cox-1) and cyclooxygenase-2 (Cox-2) are prostaglandin synthases that catalyze the formation of PGH2 from arachidonic acid (AA). Cox-1 and Cox-2 are isozymes of prostaglandin-endoperoxidase synthase (PTGS). Cox-1 is constitutively expressed in most tissues and is thought to serve in general housekeeping functions. Cox-2 is efficiently induced in migratory cells responding to pro-inflammatory stimuli and is considered to be an important mediator of inflammation. Both enzymes are targets for the nonsteroidal therapeutic anti-inflammatory drugs, NSAIDs. COX2 expression is significantly increased in 85-90% of human colorectal adenocarcinomas whereas levels of COX-1 are not changed.
Applications
IHC-P
Contrôle positif
Human colon or lung carcinoma tissue (IHC).
Recommander des dilutions
IHC: 1-2 µg/ml
Reactivité
Human
Immunogène
Recombinant fragment (around Amino Acids 400-604) of human PTGS2 protein. The exact sequence is proprietary.
Hôte
Rabbit
Clonalité
Monoclonal
Clone
COX2/7803R
Isotype
IgG
Chaînes légères
kappa
Conjuguer

Unconjugated

Purification
Protein A/G chromatography.
Concentration
1 mg/ml
Masse moléculaire
70-72 kDa
Forme du produit
Liquid
Formulation
Supplied in 10mM Phosphate Buffered Saline; without Sodium Azide and carrier free.
Stockage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Synonymes
COX 2, COX-2, Cyclooxygenase 2, Cyclooxygenase 2b, Cyclooxygenase-2, Glucocorticoid-regulated inframmatory prostagandin G/H synthase, GRIPGHS, hCox 2, PGG/HS, PGH synthase 2, PGH2_HUMAN, PGHS 2, PGHS-2, PGHS2, PHS 2, PHS II, Prostaglandin endoperoxide synthase 2, Prostaglandin endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase), Prostaglandin G/H synthase 2, Prostaglandin G/H synthase and cyclooxygenase, Prostaglandin H2 synthase 2, Prostaglandin-endoperoxide synthase 2, PTGS2
Avertissement
Ce produit est uniquement destiné à la recherche. Il n'est pas destiné à un usage diagnostique ou thérapeutique.

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