Anti-Clusterin Anticorps [CLU/4731] (A277548)

Name: Anti-Clusterin Antibody [CLU/4731]
Brand: Antibodies.com
SKU: A277548
Price: 525.0 USD
Availability: InStock

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$525

Anticorps monoclonal [CLU/4731] de souris contre Clusterin pour WB et IHC-P.

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Alternative Formats and ConjugatesAlternative Formats

Carrier Free and Preservative Free

Livraison

Frais de livraison

$40

Date de livraison

Livraison sous 4-6 jours ouvrables.

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Téléphone

+1 (314) 370-6046

E-mail

orders@antibodies.com

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Mots clés :

Anticorps Monospécifique

Spécifications

Nom du produit

Anti-Clusterin Antibody [CLU/4731]

Description du produit

Mouse monoclonal [CLU/4731] antibody to Clusterin.

Spécificité

Clusterin, also designated complement lysis inhibitor (CLI), apolipoprotein J (APOJ), sulfated glycoprotein 2 (SGP2), SP40 and testosterone-repressed prostate message 2 (TRPM2), is a secretory, heterodimeric glycoprotein that influences immune regulation, cell adhesion, transformation, lipid transportation, tissue remodeling, membrane recycling and cell-cell interactions. Clusterin is synthesized as a 449 amino acid polypeptide that is post-translationally cleaved at an internal bond between Arg 227 and Ser 228. Two subunits, Î± and Î², are associated through disulfide bonds. The Î² subunit (also called ApoJÎ±) corresponds to residues 23-227. The Î± subunit (also called ApoJÎ²) corresponds to residues 228-449. Overexpression of Clusterin appears to be more common in late stages of mammary tumor progression. Clusterin markedly influences Î²-Amyloid structure and neuritic toxicity in vivo and may influence Alzheimer s pathogenesis.

Applications

WB, IHC-P

Recommander des dilutions

WB: 2-4 µg/ml, IHC-P: 1-2 µg/ml

Reactivité

Human

Immunogène

Recombinant fragment, around amino acids 150-300, of human Clusterin protein. The exact sequence is proprietary.

Hôte

Mouse

Clonalité

Monoclonal

Clone

CLU/4731

Isotype

IgG2a

Chaînes légères

kappa

Conjuguer

Unconjugated

Purification

Protein A/G chromatography.

Concentration

200 µg/ml

Masse moléculaire

70 kDa (precursor) / 36-39 kDa (alpha) / 34-36 kDa (beta)

Forme du produit

Liquid

Formulation

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Stockage

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Notes générales

This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-Clusterin Antibody [CLU/4731] - BSA and Azide free (A278136).

Synonymes

40, AAG 4, AAG4, Aging associated protein 4, Aging-associated gene 4 protein, AI893575, APO J, Apo-J, APOJ, ApoJalpha, ApoJbeta, Apolipoprotein J, ApolipoproteinJ, CLI, CLU, CLU1, CLU2, Clusterin alpha chain, Clusterin beta chain, CLUS_HUMAN, Complement associated protein SP 40, Complement associated protein SP 40 40, Complement associated protein SP40, Complement cytolysis inhibitor, Complement cytolysis inhibitor a chain, Complement cytolysis inhibitor b chain, Complement lysis inhibitor, Complement-associated protein SP-40, D14Ucla3, Dimeric acid glycoprotein, Glycoprotein 80, Glycoprotein III, GP80, Ku70-binding protein 1, KUB 1, KUB1, MGC24903, NA1/NA2, RATTRPM2B, SGP 2, SGP2, SP 40, SP40, Sugp-2, Sulfated glycoprotein 2, Testosterone repressed prostate message 2, Testosterone-repressed prostate message 2, TRPM 2, TRPM-2, TRPM2, TRPM2B, Trpmb

Contrôles isotype

Anticorps secondaires appropriés

Avertissement

Ce produit est uniquement destiné à la recherche. Il n'est pas destiné à un usage diagnostique ou thérapeutique.

Images (3)

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Figure 1: Western Blot - Anti-Clusterin Antibody [CLU/4731] (A277548)

Western blot analysis of human testis tissue lysate using Anti-Clusterin Antibody [CLU/4731].

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Figure 2: Immunohistochemistry - Anti-Clusterin Antibody [CLU/4731] (A277548)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded human adrenal gland tissue using Anti-Clusterin Antibody [CLU/4731].

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Figure 3: Anti-Clusterin Antibody [CLU/4731] (A277548)

Analysis of protein array containing more than 19,000 full-length human proteins using Anti-Clusterin Antibody [CLU/4731]. Z-Score and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProt^TM array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If targets on HuProt^TM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target; a MAb is considered to be specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.