Anti-CD7 Antibody [B-F12] - BSA and Azide free (A253724)

Anti-CD7 Antibody [B-F12] - BSA and Azide free

Mouse monoclonal [B-F12] antibody to CD7.

This antibody recognizes a protein of 40kDa, identified as CD7 (also known as gp40, Leu9). CD7 is a member of the immunoglobulin gene superfamily. Its N-terminal amino acids 1-107 are highly homologous to Ig kappa-L chains whereas the carboxyl-terminal region of the extracellular domain is proline-rich and has been postulated to form a stalk from which the Ig domain projects. CD7 is expressed on the majority of immature and mature T-lymphocytes, and T cell leukemia. It is also found on natural killer cells, a small subpopulation of normal B cells and on malignant B cells. Cross-linking surface CD7 positively modulates T cell and NK cell activity as measured by calcium fluxes, expression of adhesion molecules, cytokine secretion and proliferation. CD7 associates directly with phosphoinositol 3'-kinase. CD7 ligation induces production of D-3 phosphoinositides and tyrosine phosphorylation.

Flow Cytometry, IF

Flow Cytometry: 1-2 µg/million cells, IF: 1-2 µg/ml

Human

Chronic Lymphoid Leukemia cells (CLL).

Mouse

Monoclonal

B-F12

IgG2a

kappa

Protein A/G chromatography.

1 mg/ml

40 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline; without Sodium Azide and carrier free.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

This monoclonal antibody is also available in a different formulation with BSA and Sodium Azide - Anti-CD7 Antibody [B-F12] (A250544).

CD27 ligand, CD27-L, CD27L, CD27LG, CD70, CD70 antigen, GP40, T-cell antigen CD7, T-cell leukemia antigen, T-cell surface antigen Leu-9, TNFSF7, TP41, Tumor necrosis factor ligand superfamily member 7