Anti-CD40 Anticorps [FGK45.5] (A254215)

Anti-CD40 Antibody [FGK45.5] - BSA and Azide free

Rat monoclonal [FGK45.5] antibody to CD40.

Upon binding to its ligand CD154, CD40 acts as a costimulatory molecule for the activation of B cells, dendritic cells, monocytes, and other APCs. CD40 plays roles in B cell activation, differentiation, proliferation and Ig isotype switching as well as dendritic cell maturation. FGK4.5 can be used for blocking of CD40/CD154 interaction and forin vitroandin vivoactivation of CD40 expressing APCs. This MAb is shown to indirectly activate natural killer (NK) cells, producing significant antitumor and anti-metastatic effects. Effective in boosting immune responses against infectious agents and can potentially be used to treat chronic autoimmune inflammatory processes.

Functional Studies, Flow Cytometry, IF

Flow Cytometry: 0.5-1 µg/million cells, IF: 1-2 µg/ml

Mouse

This antibody does not cross react with Human.

Recombinant mouse CD40 fusion protein.

Rat

Monoclonal

FGK45.5

IgG2a

kappa

Unconjugated

1 mg/ml

48 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline; without Sodium Azide and carrier free.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

This monoclonal antibody is also available in a different formulation with BSA and Sodium Azide - Anti-CD40 Antibody [FGK45.5] (A251036).

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