Anti-CD23 Anticorps [FCER2/6887] (A278189)

Name: Anti-CD23 Antibody [FCER2/6887] - BSA and Azide free
Brand: Antibodies.com
SKU: A278189
Price: 525.0 USD
Availability: InStock

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$525

Anticorps monoclonal [FCER2/6887] de souris contre CD23 pour IHC-P.

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Garantie de Correspondance des Prix

Alternative Formats and ConjugatesAlternative Formats

Unconjugated

Livraison

Frais de livraison

$40

Date de livraison

Livraison sous 4-6 jours ouvrables.

Nous ContacterContact

Téléphone

+1 (314) 370-6046

E-mail

orders@antibodies.com

Garanties

Qualité 100 % Garantie

Garantie de Correspondance des Prix

Mots clés :

Anticorps Monospécifique

Spécifications

Nom du produit

Anti-CD23 Antibody [FCER2/6887] - BSA and Azide free

Description du produit

Mouse monoclonal [FCER2/6887] antibody to CD23.

Spécificité

CD23 (FCE2) is a type II integral membrane glycoprotein that is expressed on mature B cells, monocytes, eosinophils, platelets and dendritic cells. CD23 is a low affinity IgE receptor that mediates IgE-dependent cytotoxicity and phagocytosis by macrophages and eosinophils. CD23 associates as an oligomer where cooperative binding of at least two lectin domains is required for high affinity IgE binding to CD23. It may play a role in antigen presentation by B cells by interacting with CD40. CD23 has been shown to be associated with the Fyn tyrosine kinase. The truncated molecule can be secreted, then function as a potent mitogenic growth factor. CD23 is expressed on a subpopulation of peripheral blood cells, B-lymphocytes and on EBV transformed B lymphoblastoid cell lines. CD23 is also detected in neoplastic cells from cases of B cell chronic lymphocytic leukemia and some cases on centroblastic/centrocytic lymphoma.

Applications

IHC-P

Recommander des dilutions

IHC-P: 1-2 µg/ml

Reactivité

Human

Immunogène

Recombinant fragment, around amino acids 48-321, of human CD23 protein. The exact sequence is proprietary.

Hôte

Mouse

Clonalité

Monoclonal

Clone

FCER2/6887

Isotype

IgG2b

Chaînes légères

kappa

Conjuguer

Unconjugated

Purification

Protein A/G chromatography.

Concentration

1 mg/ml

Masse moléculaire

37 kDa (soluble form) / 45 kDa (membrane-bound form)

Forme du produit

Liquid

Formulation

Supplied in 10mM Phosphate Buffered Saline; without Sodium Azide and carrier free.

Stockage

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Notes générales

This monoclonal antibody is also available in a different formulation with BSA and Sodium Azide - Anti-CD23 Antibody [FCER2/6887] (A277601).

Synonymes

BLAST 2, BLAST-2, Blast2, C type lectin domain family 4 member J, C-type lectin domain family 4 member J, C-type lectin domain family 4, member J, CD 23, CD 23A, CD23 antigen, CD23A, CLEC 4J, CLEC4J, Fc epsilon receptor II, Fc epsilon RII, Fc fragment of IgE low affinity II receptor for, Fc fragment of IgE low affinity II receptor for (CD23), Fc fragment of IgE receptor II, Fc fragment of IgE, low affinity II, receptor for (CD23), Fc of IgE, low affinity II, receptor for (CD23), Fc receptor IgE low affinity II alpha polypeptide, Fc receptor, IgE, low affinity II, alpha polypeptide, isoform CRA_a, Fc-epsilon-RII, FCE 2, FCE2, FCER 2, Fcer2, FCER2A, FCER2_HUMAN, FceRII, IgE binding factor, IgE receptor lymphocyte, IgE-binding factor, IGEBF, Immunoglobulin E binding factor, Immunoglobulin E receptor, low affinity II, Immunoglobulin E-binding factor, Immunoglobulin epsilon chain, LEUKOCYTE ANTIGEN CD23, Low Affinity IgE Receptor, Low affinity immunoglobulin epsilon Fc receptor, Low affinity immunoglobulin epsilon Fc receptor membrane bound form, Low affinity immunoglobulin epsilon Fc receptor soluble form, Ly-42, Ly42, Lymphocyte antigen CD23, Lymphocyte IgE receptor, MGC93219

Contrôles isotype

Anticorps secondaires appropriés

Avertissement

Ce produit est uniquement destiné à la recherche. Il n'est pas destiné à un usage diagnostique ou thérapeutique.

Images (4)

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Figure 1: SDS-PAGE - Anti-CD23 Antibody [FCER2/6887] - BSA and Azide free (A278189)

SDS-PAGE analysis of Anti-CD23 Antibody [FCER2/6887] under non-reduced and reduced conditions; showing intact IgG and intact heavy and light chains, respectively. SDS-PAGE analysis confirms the integrity and purity of the antibody.

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Figure 2: Immunohistochemistry - Anti-CD23 Antibody [FCER2/6887] - BSA and Azide free (A278189)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded human tonsil using Anti-CD23 Antibody [FCER2/6887] at 2µg/ml in PBS for 30 minutes at room temperature. Inset: PBS instead of the primary antibody. Secondary antibody negative control.

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Figure 3: Immunohistochemistry - Anti-CD23 Antibody [FCER2/6887] - BSA and Azide free (A278189)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded human lymph node using Anti-CD23 Antibody [FCER2/6887] at 2µg/ml in PBS for 30 minutes at room temperature.

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Figure 4: Anti-CD23 Antibody [FCER2/6887] - BSA and Azide free (A278189)

Analysis of protein array containing more than 19,000 full-length human proteins using Anti-CD23 Antibody [FCER2/6887]. Z-Score and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProt^TM array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If targets on HuProt^TM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target; a MAb is considered to be specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.