This antibody recognises human SIRP gamma, a 55 kDa signal regulatory protein which is a member of the immunoglobulin gene superfamily. SIRP gamma, also known as CD172g, is expressed on most T lymphocytes and a subset of B-cells but is absent on myeloid cells. CD172g has a truncated cytoplasmic tail, which is similar to SIRP beta, but unlike SIRP beta CD172g does not require DAP12 for expression at the cell surface. CD172g, like SIRP alpha, binds to CD47 inducing apoptosis. It is also involved in the negative regulation of receptor tyrosine kinase-coupled signalling.

Applications

IP, Flow Cytometry

Recommander des dilutions

Flow Cytometry: 1:50 - 1:200, Use 10µl of the suggested working dilution to label 1x10⁶ cells in 100µl.

Reactivité

Human

Immunogène

Purified recombinant SIRP gamma.CD4.

Hôte

Mouse

Clonalité

Monoclonal

Clone

OX119

Isotype

IgG1

Conjuguer

Unconjugated

Purification

Protein G affinity chromatography of tissue culture supernatant.

Concentration

1 mg/ml

Forme du produit

Liquid

Formulation

Supplied in Phosphate Buffered Saline with 0.09% Sodium Azide.

Stockage

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

Notes générales

Mouse anti Human CD172g antibody, clone OX119 recognizes human SIRP gamma, a 55 kDa signal regulatory protein which is a member of the immunoglobulin gene superfamily. SIRP gamma, also known as CD172g, is expressed on most T lymphocytes and a subset of B-cells but is absent on myeloid cells. CD172g has a truncated cytoplasmic tail, which is similar to SIRP beta, but unlike SIRP beta CD172g does not require DAP12 for expression at the cell surface. CD172g, like SIRP alpha, binds to CD47 inducing apoptosis. It is also involved in the negative regulation of receptor tyrosine kinase-coupled signalling.

Synonymes

bA77C3.1, CD172 antigen like family member B, CD172 antigen-like family member B, CD172g, CD172g antigen, FLJ42230, RP11-77C3.2, Signal regulatory protein beta 2, Signal regulatory protein gamma, Signal-regulatory protein beta-2, Signal-regulatory protein gamma, SIRP B2, SIRP beta 2, SIRP gamma, SIRP-b2, SIRP-beta-2, SIRP-gamma, SIRPB2, SIRPG, SIRPgamma, SIRPG_HUMAN

Contrôles isotype

Anticorps secondaires appropriés

Avertissement

Ce produit est uniquement destiné à la recherche. Il n'est pas destiné à un usage diagnostique ou thérapeutique.