Anti-CD137 Anticorps [17B5] (A279050)

Anti-CD137 Antibody [17B5]

Hamster monoclonal [17B5] antibody to CD137.

This antibody recognises mouse CD137, also known as 4-1BB ligand receptor, a member of the tumour necrosis factor superfamily. CD137 is a potent costimulatory receptor for the growth and functional maturation of activated T-cells in the presence of T-cell receptor signal. It is found on activated T-cells, NK cells, monocytes and dendritic cells. Signalling through CD137 triggers T-cell expansion, cytokine production and prevention of activation-induced death of effector T-cells. CD137-mediated activation is distinct from and independent of CD28. Antibody cross-linking of CD137 on NK cells stimulates the secretion of IFN-gamma, cellular proliferation, CD25 expression and responsiveness to IL-2 and is associated with tumour activity, but not cytotoxicity.Hamster anti Mouse CD137 antibody, clone 17B5 may be used to block CD137-mediated T-cell proliferation.

Flow Cytometry

Use 10µl of the suggested working dilution to label 1x10⁶ cells in 100µl.

Mouse

Hamster

Monoclonal

17B5

IgG

Unconjugated

1 mg/ml

Liquid

Supplied in Phosphate Buffered Saline with 0.09% Sodium Azide.

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

Hamster anti Mouse CD137 antibody, clone 17B5 recognizes mouse CD137, also known as 4-1BB ligand receptor, a member of the tumour necrosis factor superfamily. CD137 is a potent costimulatory receptor for the growth and functional maturation of activated T-cells in the presence of T-cell receptor signal. It is found on activated T-cells, NK cells, monocytes and dendritic cells. Signalling through CD137 triggers T-cell expansion, cytokine production and prevention of activation-induced death of effector T-cells. CD137-mediated activation is distinct from and independent of CD28. Antibody cross-linking of CD137 on NK cells stimulates the secretion of IFN-gamma, cellular proliferation, CD25 expression and responsiveness to IL-2 and is associated with tumour activity, but not cytotoxicity.Hamster anti Mouse CD137 antibody, clone 17B5 may be used to block CD137-mediated T-cell proliferation.

4 1BB, 4 1BB ligand receptor, 4-1BB ligand receptor, 4-1BB Ligand Receptor T Cell, 4-1BB, mouse, homolog of, Antigen 4-1BB Homolog, CD 137, CD137 antigen, CDw137, HLDA VI, Homolog of mouse 4 1BB, ILA, Induced by lymphocyte activation, induced by lymphocyte activation (ILA), Interleukin activated receptor homolog of mouse Ly63, Ly63, mouse, homolog of, MGC2172, OTTHUMP00000044294, Receptor protein 4 1BB, T cell antigen 4 1BB homolog, T cell antigen ILA, T-cell antigen 4-1BB homolog, T-cell antigen ILA, TNF receptor superfamily member 9, TNFRSF9, TNR9_HUMAN, Tumor necrosis factor receptor superfamily member 9