This antibody recognises human CD193, otherwise known as CC chemokine receptor 3 (CCR3), a seven-helix transmembrane G-protein coupled receptor which, along with CCR5 and CXCR4, acts as a principal receptor for the fusion and entry of HIV into target cells. CD193 is expressed by eosinophils, basophils, mast cells, microglia, Th2 helper cells and some epithelial cells.CD193 acts as a receptor for several CC chemokines including monocyte chemoattractant proteins (MCP) -1, -2, -3 and -4, MIP-1a, MIP-1ß, and RANTES. The eotaxin subgroup of CC chemokines act as specific agonists for CD193 involved in infection of microglia by HIV and allergic reactions. Rabbit anti Human CD193 antibody has been used successfully for the detection of human CD193 by immunohistochemistry on formalin fixed, paraffin embedded intervertebral disc tissue.

Applications

WB, IHC-P, IF, IHC-Fr

Recommander des dilutions

IHC-P 1: 10 µg/ml, WB: 1 µg/ml

Reactivité

Human, Rat, Mouse

Immunogène

Synthetic peptide corresponding to 14 amino acids near human CD193 carboxy-terminus.

Hôte

Rabbit

Clonalité

Polyclonal

Isotype

IgG

Conjuguer

Unconjugated

Concentration

1 mg/ml

Masse moléculaire

Approximately 55 kDa in human spleen cell lysates (predicted Mwt. 41 kDa)

Forme du produit

Liquid

Formulation

Supplied in Phosphate Buffered Saline with 0.02% Sodium Azide.

Stockage

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

Notes générales

Rabbit anti Human CD193 antibody recognizes human CD193, otherwise known as CC chemokine receptor 3 (CCR3), a seven-helix transmembrane G-protein coupled receptor which, along with CCR5 and CXCR4, acts as a principal receptor for the fusion and entry of HIV into target cells. CD193 is expressed by eosinophils, basophils, mast cells, microglia, Th2 helper cells and some epithelial cells.CD193 acts as a receptor for several CC chemokines including monocyte chemoattractant proteins (MCP) -1, -2, -3 and -4, MIP-1a, MIP-1ß, and RANTES. The eotaxin subgroup of CC chemokines act as specific agonists for CD193 involved in infection of microglia by HIV (He et al. 1997) and allergic reactions (Holse et al. 2006).Rabbit anti Human CD193 antibody has been used successfully for the detection of human CD193 by immunohistochemistry on formalin fixed, paraffin embedded intervertebral disc tissue (Gruber et al. 2014).

Synonymes

B chemokine receptor, b-chemokine receptor, C C chemokine receptor type 3, C C CKR 3, C-C chemokine receptor type 3, C-C CKR-3, CC chemokine receptor 3, CC chemokine receptor type 3, CC CKR 3, CC R3, CC-CKR-3, CCCKR3, CCR 3, CCR-3, CCR3_HUMAN, CD 193, CD193, CD193 antigen, Chemokine (C C motif) receptor 3, chemokine (C-C motif) receptor 3, Chemokine (CC) receptor 1 like 2, Chemokine CC motif receptor 3, Chemokine receptor 3, CK R3, CKR 3, CKR3, CMKB R3, CMKBR 3, CMKBR1L2, CMKBR3, Eosinophil CC chemokine receptor 3, Eosinophil eotaxin receptor, Eotaxin receptor, Macrophage inflammatory protein 1 alpha receptor like 2, MGC102841, MIP1 Alpha RL2

Contrôles isotype

Anticorps secondaires appropriés

Avertissement

Ce produit est uniquement destiné à la recherche. Il n'est pas destiné à un usage diagnostique ou thérapeutique.