Anti-Carboxypeptidase A Anticorps [CPA1/8784] (A314548)

Anti-Carboxypeptidase A Antibody [CPA1/8784]

Mouse monoclonal [CPA1/8784] antibody to Carboxypeptidase A.

Human pancreatic procarboxypeptidase A exists as three different active forms, two of which are designated carboxypeptidase A1 (CPA1) and carboxypeptidase A2 (CPA2). CPA1, also known as CPA, is a 419 amino acid secreted monomeric protein that is highly expressed in pancreatic tissue. Functioning as a pancreatic exopeptidase, CPA1 uses zinc as a cofactor to catalyze the release of C-terminal amino acids from a variety of proteins, thereby playing a key role in protein digestion and degradation. Via its catalytic activity, CPA1 is also thought to be involved in zymogen (proenzyme) inhibition, probably functioning to block enzyme activation pathways. Abnormal levels of CPA1 are associated with pancreatic cancer, suggesting a possible role in either tumor progression or tumor suppression events.

IHC-P

Pancreas.

IHC: 1-2 µg/ml

Human

Recombinant full-length human CPA1 protein.

Mouse

Monoclonal

CPA1/8784

kappa

Unconjugated

Protein A/G chromatography.

200 µg/ml

47 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Carboxypeptidase A1, carboxypeptidase A1 (pancreatic), Carboxypeptidase A1 precursor, CBPA1_HUMAN, CPA, CPA1, Pancreatic carboxypeptidase A1, Procarboxypeptidase A1 pancreatic