Anti-Calcitonin Anticorps [CALCA/3310] (A278417)

Anti-Calcitonin Antibody [CALCA/3310] - BSA and Azide free

Mouse monoclonal [CALCA/3310] antibody to Calcitonin.

Calcitonin is a 32 amino acid polypeptide hormone that preserves skeletal integrity and reduces blood calcium levels by decreasing osteoclast activity in bones, calcium and phosphate reabsorption by kidney tubules and calcium absorption by the intestines. The secretion of Calcitonin from the thyroid is regulated in part by estrogen, which increases Calcitonin mRNA levels. The Calcitonin gene, CALCA, undergoes tissue-specific RNA alternative splicing, resulting in the production of different mRNA transcripts. One transcript encodes procalcitonin as well as both calcium-lowering processed active polypeptides, Calcitonin and katacalcin. An alternative transcript of CALCA encodes the precursor for the neuropeptide referred to as Calcitonin generelated peptide 1, also designated CGRP1 or α-CGRP. CGRP is a widely distributed vasodilatory peptide. Calcitonin and katacalcin are produced primarily in the thyroid, while CGRP is produced in neuronal cells. A second CGRP related gene, CALCB, thought to be derived from an gene duplication event, has been identified in mouse, rat and human. Unlike CALCA, CALCB is not subject to alternative splicing and encodes a single transcript designated CGRP2 or β-CGRP. Mature CGRP1 and CGRP2 share significant sequence identity at the protein level differing by only 1-3 amino acid residues, depending on the species.

IHC-P

IHC-P: 1:10-1:20

Human

Recombinant fragment, around amino acids 3-116, of human Calcitonin protein. The exact sequence is proprietary.

Mouse

Monoclonal

CALCA/3310

kappa

Unconjugated

Protein A/G chromatography.

1 mg/ml

14.5 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline; without Sodium Azide and carrier free.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

This monoclonal antibody is also available in a different formulation with BSA and Sodium Azide - Anti-Calcitonin Antibody [CALCA/3310] (A277829).

Alpha CGRP, alpha type CGRP, CALC 1, CALC A, CALC1, calcitonin 1, calcitonin gene related peptide 1, calcitonin gene related peptide I, calcitonin related polypeptide alpha, CGRP, CGRP 1, CGRP I, CGRP1, CT, katacalcin, KC