This antibody recognises complement component 9 (C9), a 71 kDa member of the complement C6/C7/C8/C9 family present in the blood serum and synthesised by the liver and monocytes. C9 is the last component to be added during the formation of the membrane attack complex (MAC), binding the membrane associated C5b-8 complex and resulting in the circular polymerisation of 12-18 C9 molecules. This forms the hydrophilic transmembrane channel which causes cell lysis. Deficiency of C9 is associated with recurring infections by Neisseria meningitides. Mouse anti Human C9 antibody, clone 002-94.8.8 does not recognise MAC.
Applications
ELISA
Reactivité
Human
Immunogène
Purified human C9.
Hôte
Mouse
Clonalité
Monoclonal
Clone
002-94.8.8
Isotype
IgG2b
Conjuguer
Unconjugated
Purification
Protein A affinity chromatography of ascites.
Concentration
1 mg/ml
Forme du produit
Liquid
Formulation
Supplied in Borate Buffered Saline with 0.1% Sodium Azide.
Stockage
Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.
Notes générales
Mouse anti Human C9 antibody, clone 002-94.8.8 recognises complement component 9 (C9), a 71 kDa member of the complement C6/C7/C8/C9 family present in the blood serum and synthesised by the liver and monocytes. C9 is the last component to be added during the formation of the membrane attack complex (MAC), binding the membrane associated C5b-8 complex and resulting in the circular polymerisation of 12-18 C9 molecules. This forms the hydrophilic transmembrane channel which causes cell lysis. Deficiency of C9 is associated with recurring infections by Neisseria meningitides.Mouse anti Human C9 antibody, clone 002-94.8.8 does not recognise MAC.
