Anti-C4d Anticorps [SPM545] (A253396)

Anticorps monoclonal [SPM545] de souris contre C4d pour IF et IHC-P.

Alternative Formats and ConjugatesAlternative Formats

Frais de livraison
Date de livraison
Livraison sous 4-6 jours ouvrables.
Téléphone
+1 (314) 370-6046
Lun - Ven, 8h - 16h AST
E-mail
orders@antibodies.com
Nom du produit
Anti-C4d Antibody [SPM545] - BSA and Azide free
Description du produit
Mouse monoclonal [SPM545] antibody to C4d.
Spécificité
This antibody is specific to Complement 4d (C4d) and it reacts with the secreted as well as cell-bound C4d.C4d is a degradation product of the activated complement factor C4b. Complement 4b is typically activated by binding of Abs to specific target molecules. Following activation and degradation of the C4 molecule, thio-ester groups are exposed, which allow transient, covalent binding of the degradation product Complement 4d to endothelial cell surfaces and extracellular matrix components of vascular basement membranes near the sites of C4 activation. The presence of C4d in peritubular capillaries is a key indicator for acute humoral (i.e. antibody-mediated) rejection of kidney, heart, pancreas and lung allografts. As an established marker of antibody-mediated acute renal allograft rejection and its proclivity for endothelium, this component can be detected in peritubular capillaries in chronic renal allograft rejection as well as hyperacute rejection, acute vascular rejection, acute cellular rejection, and borderline rejection. It has been shown to be a significant predictor of transplant kidney graft survival. Anti-C4d, combined with anti-C3d, can be utilized as a tool for diagnosis of allograft rejection that may warrant a prompt and aggressive anti-rejection treatment.
Applications
IF, IHC-P
Recommander des dilutions
IF: 1:50-1:100, IHC-P: 1:200-1:400
Reactivité
Human
Immunogène
Recombinant human Complement 4d protein.
Hôte
Mouse
Clonalité
Monoclonal
Clone
SPM545
Isotype
IgG1
Chaînes légères
kappa
Conjuguer

Unconjugated

Purification
Protein A/G chromatography.
Concentration
1 mg/ml
Masse moléculaire
192 kDa (predicted)
Forme du produit
Liquid
Formulation
Supplied in 10mM Phosphate Buffered Saline; without Sodium Azide and carrier free.
Stockage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Notes générales
This monoclonal antibody is also available in a different formulation with BSA and Sodium Azide - Anti-C4d Antibody [SPM545] (A250216).
Synonymes
acidic C4, Acidic complement C4, basic C4, basic complement C4, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 2, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 3, C4, C4, chido form, C4, Rodgers form, C4-1, C4A, C4a anaphylatoxin, C4A2, C4A3, C4A4, C4A6, C4AD, C4b, C4B1, C4B12, C4B2, C4B3, C4B5, C4BD, C4B_2, C4d fragment, C4F, C4S, CH, Chido form of C4, CO4, CO4A_HUMAN, Complement C4 gamma chain, complement C4-A, complement C4-B, complement C4-B-like, complement C4B1a, Complement component 4A, complement component 4A (Rodgers blood group), Complement component 4B, complement component 4B (Chido blood group), complement component 4B (Chido blood group), copy 2, complement component 4B (Chido blood group)-like, Complement component 4F, Complement component 4S, CPAMD2, CPAMD3, DADB-112B14.11, MGC164979, RG, Rodgers form of C4
Avertissement
Ce produit est uniquement destiné à la recherche. Il n'est pas destiné à un usage diagnostique ou thérapeutique.

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