Anti-C4d Anticorps [C4D204] (CF® 488) (A251155)

Ce produit est discontinué

Anti-C4d Anticorps [C4D204] (CF® 488) (A251155) a été abandonné et n'est plus disponible.

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Nom du produit
Anti-C4d Antibody [C4D204] (CF® 488)
Description du produit
Mouse monoclonal [C4D204] antibody to C4d (CF® 488).
Spécificité
This antibody is specific to Complement 4d (C4d) and reacts with the secreted as well as cell-bound C4d.C4d is a degradation product of the activated complement factor C4b. Complement 4b is typically activated by binding of Abs to specific target molecules. Following activation and degradation of the C4 molecule, thio-ester groups are exposed, which allow transient, covalent binding of the degradation product Complement 4d to endothelial cell surfaces and extracellular matrix components of vascular basement membranes near the sites of C4 activation. The presence of C4d in peritubular capillaries is a key indicator for acute humoral (i.e. antibody-mediated) rejection of kidney, heart, pancreas and lung allografts. As an established marker of antibody-mediated acute renal allograft rejection and its proclivity for endothelium, this component can be detected in peritubular capillaries in chronic renal allograft rejection as well as hyperacute rejection, acute vascular rejection, acute cellular rejection, and borderline rejection. It has been shown to be a significant predictor of transplant kidney graft survival. Anti-C4d, combined with anti-C3d, can be utilized as a tool for diagnosis of allograft rejection that may warrant a prompt and aggressive anti-rejection treatment.
Applications
ELISA, IF, IHC-P
Recommander des dilutions
ELISA: 1-2 µg/ml, IF: 1:50-1:100, IHC-P: 1:200-1:400
Reactivité
Human
Immunogène
Recombinant human Complement 4d protein.
Hôte
Mouse
Clonalité
Monoclonal
Clone
C4D204
Isotype
IgG1
Chaînes légères
kappa
Conjuguer

CF® 488

Excitation: 490nm, Emission: 515nm

Purification
Protein A/G chromatography.
Concentration
100 µg/ml
Masse moléculaire
192 kDa (predicted)
Forme du produit
Liquid
Formulation
Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.
Stockage
Store at 4-8°C. Antibody is stable for 24 months.
Synonymes
acidic C4, Acidic complement C4, basic C4, basic complement C4, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 2, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 3, C4, C4, chido form, C4, Rodgers form, C4-1, C4A, C4a anaphylatoxin, C4A2, C4A3, C4A4, C4A6, C4AD, C4b, C4B1, C4B12, C4B2, C4B3, C4B5, C4BD, C4B_2, C4d fragment, C4F, C4S, CH, Chido form of C4, CO4, CO4A_HUMAN, Complement C4 gamma chain, complement C4-A, complement C4-B, complement C4-B-like, complement C4B1a, Complement component 4A, complement component 4A (Rodgers blood group), Complement component 4B, complement component 4B (Chido blood group), complement component 4B (Chido blood group), copy 2, complement component 4B (Chido blood group)-like, Complement component 4F, Complement component 4S, CPAMD2, CPAMD3, DADB-112B14.11, MGC164979, RG, Rodgers form of C4
Avertissement
Ce produit est uniquement destiné à la recherche. Il n'est pas destiné à un usage diagnostique ou thérapeutique.
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