This antibody recognises human complement component 3d (C3d), a ~33 kDa polypeptide fragment generated over the course of complement activation where complement 3 (C3) convertases cleave C3 to C3b, which is further degraded into iC3b and C3dg/C3d. C3d is involved in the regulation of many aspects of the immune response, including antigen processing and presentation. The C3d/antigen complex mediates B cell activation by simultaneously binding antigen-specific surface bound immunoglobulin and CD21, lowering the complement activation threshold. C3 is crucial in the induction of tolerance generated when an antigen is introduced into immunoprivileged sites and this is exploited by pathogens and cancer cells to evade the immune system by inhibiting complement activation.

Applications

Flow Cytometry, ELISA, IHC-Fr, WB

Recommander des dilutions

WB: 1:5,000

Reactivité

Human

Immunogène

Purified C3d from human plasma.

Hôte

Mouse

Clonalité

Monoclonal

Clone

053A-1149.3.1.4

Isotype

IgG1

Conjuguer

Unconjugated

Purification

Protein A affinity chromatography of ascites.

Concentration

Lot Specific

Forme du produit

Liquid

Formulation

Supplied in Borate Buffered Saline with 0.1% Sodium Azide.

Stockage

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

Notes générales

Mouse anti Human C3d antibody, clone 053A-1149.3.1.4, also known as 1003, recognizes human complement component 3d (C3d), a ~33 kDa polypeptide fragment generated over the course of complement activation where complement 3 (C3) convertases cleave C3 to C3b, which is further degraded into iC3b and C3dg/C3d. C3d is involved in the regulation of many aspects of the immune response, including antigen processing and presentation. The C3d/antigen complex mediates B cell activation by simultaneously binding antigen-specific surface bound immunoglobulin and CD21, lowering the complement activation threshold. C3 is crucial in the induction of tolerance generated when an antigen is introduced into immunoprivileged sites and this is exploited by pathogens and cancer cells to evade the immune system by inhibiting complement activation.

Synonymes

Acylation stimulating protein cleavage product, AHUS5, ARMD9, ASP, C3, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1, CO3_HUMAN, Complement C3, Complement C3c alpha' chain fragment 2, Complement C3d fragment, Complement component 3, Complement component C3, CPAMD1

Contrôles isotype

Anticorps secondaires appropriés

Avertissement

Ce produit est uniquement destiné à la recherche. Il n'est pas destiné à un usage diagnostique ou thérapeutique.