This antibody recognises human complement component 1 q (C1q), a ~156 kDa secreted protein. C1q associates with proenzymes C1r and C1s to form the calcium-dependent C1 complex, the first component of the serum complement system. C1q is composed of six A-, six B-chains and six C-polypeptide chains. Each chain contains a collagen-like region located near the N-terminus and a C-terminal globular region. These regions bind the Fc region of IgM and IgG molecules, initiating the classical pathway of complement activation. C1q deficiency has been associated with lupus erythematosus and glomerulonephritis.

Applications

Flow Cytometry, ELISA, IHC-Fr, WB, IF

Recommander des dilutions

IHC-Fr: 1:500 - 1:1,000

Reactivité

Human

Immunogène

Globular head domain of C1q, purified from human plasma.

Hôte

Mouse

Clonalité

Monoclonal

Clone

004-43.X (3R9/2)

Isotype

IgG1

Conjuguer

Unconjugated

Purification

Protein A affinity chromatography of ascites.

Concentration

Lot Specific

Forme du produit

Liquid

Formulation

Supplied in Borate Buffered Saline with 0.09% Sodium Azide.

Stockage

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

Notes générales

Mouse anti human C1q antibody, clone 004-43.X (3R9/2), recognizes human complement component 1 q (C1q), a ~156 kDa secreted protein. C1q associates with proenzymes C1r and C1s to form the calcium-dependent C1 complex, the first component of the serum complement system. C1q is composed of six A-, six B-chains and six C-polypeptide chains. Each chain contains a collagen-like region located near the N-terminus and a C-terminal globular region. These regions bind the Fc region of IgM and IgG molecules, initiating the classical pathway of complement activation. C1q deficiency has been associated with lupus erythematosus and glomerulonephritis (Troedson et al. 2013).

Synonymes

C1qa, C1QA_HUMAN, C1QB, C1QC, Complement C1q subcomponent subunit A, Complement C1q subcomponent subunit B, Complement C1q subcomponent subunit C, Complement component 1 q subcomponent alpha polypeptide, Complement component C1q A chain, Complement component C1q B chain, Complement component C1q C chain

Contrôles isotype

Anticorps secondaires appropriés

Avertissement

Ce produit est uniquement destiné à la recherche. Il n'est pas destiné à un usage diagnostique ou thérapeutique.