Anti-C1q Antibody [004-43.X (3R9/2)] (A278892)

Anti-C1q Antibody [004-43.X (3R9/2)]

Mouse monoclonal [004-43.X (3R9/2)] antibody to C1q.

This antibody recognises human complement component 1 q (C1q), a ~156 kDa secreted protein. C1q associates with proenzymes C1r and C1s to form the calcium-dependent C1 complex, the first component of the serum complement system. C1q is composed of six A-, six B-chains and six C-polypeptide chains. Each chain contains a collagen-like region located near the N-terminus and a C-terminal globular region. These regions bind the Fc region of IgM and IgG molecules, initiating the classical pathway of complement activation. C1q deficiency has been associated with lupus erythematosus and glomerulonephritis.

Flow Cytometry, ELISA, IHC-Fr, WB, IF

IHC-Fr: 1:500 - 1:1,000

Human

Globular head domain of C1q, purified from human plasma.

Mouse

Monoclonal

004-43.X (3R9/2)

IgG1

Lot Specific

Liquid

Supplied in Borate Buffered Saline with 0.09% Sodium Azide.

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

Mouse anti human C1q antibody, clone 004-43.X (3R9/2), recognizes human complement component 1 q (C1q), a ~156 kDa secreted protein. C1q associates with proenzymes C1r and C1s to form the calcium-dependent C1 complex, the first component of the serum complement system. C1q is composed of six A-, six B-chains and six C-polypeptide chains. Each chain contains a collagen-like region located near the N-terminus and a C-terminal globular region. These regions bind the Fc region of IgM and IgG molecules, initiating the classical pathway of complement activation. C1q deficiency has been associated with lupus erythematosus and glomerulonephritis (Troedson et al. 2013).

Complement C1q subcomponent subunit A