Notes générales
Mouse anti Human C-reactive protein antibody, clone F03-2C7 recognizes, C-reactive protein (CRP). CRP is a member of the pentaxin family of proteins which target and activate various stages of the complement system. CRP is known to exist in 2 states, either as a monomer (mCRP) or as a pentamer (pCRP), where the pantamer is composed of 5 nearly identical subunits. The monomeric and pentameric forms have similar functions, but their relative abundance differs across various tissues. For example, pCRP is present in plasma, while mCRP is present mostly in the surface of damaged cells and platelets (Wu et al. 2015). In humans, levels of CRP increases 1,000-fold within 24 to 48 hours of infection, inflammation or tissue damage (Black et al. 2004). In response to infection or tissue damage Interleukin-6, Interleukin-1 beta or glucocorticoids induce hepatocyte production of CRP. Available CRP can then detect foreign invading microorganisms, by binding carbohydrate structures. CRP is also able to bind modified low density lipoproteins and cells undergoing cell death, to assist with phagocytosis and clearance mechanisms. This is directly co-ordinated via CRP and other pentaxin proteins to prevent excessive tissue damage and clearance of any injured tissue components.This biotinylated Mouse anti Human C-reactive protein antibody, clone F03-2C7 (MCA6187B) can be used as a detection antibody in a sandwich ELISA with the purified Mouse anti Human C-reactive protein antibody, clone F01-1G4 (MCA6186GA) as the capture antibody.
