Anti-BCMA Antibody [rCD269/8507] - BSA and Azide free
Description du produit
Recombinant mouse monoclonal [rCD269/8507] antibody to BCMA.
Spécificité
The B cell maturation protein (BCMA) is a type I integral membrane protein that belongs to the tumor necrosis factor receptor (TNF-R) superfamily. It is expressed as a 184 amino acid peptide that is expressed only in mature B-lymphocytes and is located on the cis part of the Golgi apparatus. BCMA shares significant homology with TACI (transmembrane activator) within the cysteine-rich domain. TACI has been shown to bind CAML, which induces activation of NFAT (nuclear factor of activated T cells). Both BCMA and TACI have been shown to bind APRIL and TALL-1, which stimulate B cell proliferation in conjunction with other B-cell activators. When overexpressed, TALL-1 stimulates the development of systemic lupus erythaematosus (SLE).
Applications
ELISA, IHC-P
Contrôle positif
NAMALWA cells. Tonsil or gastric carcinoma (IHC).
Recommander des dilutions
IHC: 1-2 µg/ml
Reactivité
Human
Immunogène
Recombinant human CD269 protein fragment (around Amino Acids 1-184). The exact sequence is proprietary.
Hôte
Mouse
Clonalité
Monoclonal
Clone
rCD269/8507
Isotype
IgG1
Chaînes légères
kappa
Conjuguer
Unconjugated
Purification
Protein A/G chromatography.
Concentration
1 mg/ml
Masse moléculaire
20 kDa
Forme du produit
Liquid
Formulation
Supplied in 10mM Phosphate Buffered Saline; without Sodium Azide and carrier free.
Stockage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Synonymes
B cell maturation antigen, B cell maturation factor, B cell maturation protein, B-cell maturation protein, BCM, CD269, CD269 antigen, TNFRSF17, TNR17_HUMAN, Tumor necrosis factor receptor superfamily member 17