Anti-BAP1 Anticorps [BAP1/2433] (A250409)

Anti-BAP1 Antibody [BAP1/2433]

Mouse monoclonal [BAP1/2433] antibody to BAP1.

The BAP1 gene belongs to the ubiquitin C-terminal hydrolase subfamily of de-ubiquitination enzymes that are involved in the removal of ubiquitin from proteins. The encoded enzyme binds to the breast cancer type 1 susceptibility protein (BRCA1) via the RING finger domain of the latter and acts as a tumor suppressor. In addition, the enzyme may be involved in regulation of transcription, regulation of cell cycle and growth, response to DNA damage and chromatin dynamics. Germ line mutations in this gene may be associated with tumor predisposition syndrome (TPDS), which involves increased risk of cancers including malignant mesothelioma, Uveal melanoma and cutaneous melanoma.

IHC-P

IHC-P: 1-2 µg/ml

Human

Recombinant fragment, around amino acids 191-326, of human BAP1 protein. The exact sequence is proprietary.

Mouse

Monoclonal

BAP1/2433

IgG

Protein A/G chromatography.

200 µg/ml

91 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-BAP1 Antibody [BAP1/2433] - BSA and Azide free (A253589).

BAP 1, BAP1_HUMAN, BRCA 1 associated protein 1, BRCA1 associated protein 1, BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase), BRCA1-associated protein 1, Cerebral protein 13, Cerebral protein 6, DKFZp686N04275, FLJ35406, FLJ37180, HUCEP 13, Hucep 6, HUCEP13, Hucep6, KIAA0272, TPDS, Ubiquitin carboxy terminal hydrolase, Ubiquitin carboxyl terminal hydrolase BAP 1, Ubiquitin carboxyl terminal hydrolase BAP1, Ubiquitin carboxyl-terminal hydrolase BAP1, UCHL2