Anti-Bag1 Anticorps (A283041)

$645

Anticorps polyclonal de lapin contre Bag1 pour WB.

Frais de livraison
Date de livraison
Livraison sous 4-6 jours ouvrables.
Téléphone
+1 (314) 370-6046
Lun - Ven, 8h - 16h AST
E-mail
orders@antibodies.com
Nom du produit
Anti-Bag1 Antibody
Description du produit
Rabbit polyclonal antibody to Bag1.
Spécificité
This antibody recognises the C-terminal (CT) region of Bcl-2 associated athanogene-1 (BAG1), a co-chaperone protein which binds to and regulates the 70 kDa heat shock proteins (Hsp70/Hsc70). BAG1 has also been shown to interact with the kinase Raf1, a number of steroid and tyrosine kinase receptors, and the Bcl-2 family of proteins. It is thought to function as a molecular switch between cell growth and differentiation, and cell survival. The BAG1 gene encodes three different isoforms; a predominantly cytosolic form of ~36 kDa (BAG1S), a ~46 kDa cytosolic and nuclear form (BAG1M), and a predominantly nuclear form ~50 kD (BAG1L).BAG1 displays potent neuroprotective activity in vivo against stroke, and could be used for reducing brain injury during cerebral ischemia and neurodegenerative diseases. BAG1 may also promote chemoresistance, growth factor independence, and anchorage independent cell growth in tumour cells.
Applications
WB
Recommander des dilutions
WB: 1 - 2 µg/ml
Reactivité
Human, Rat, Mouse
Immunogène
A peptide corresponding to 14 amino acids near the C-terminus of human BAG1.
Hôte
Rabbit
Clonalité
Polyclonal
Isotype
IgG
Conjuguer

Unconjugated

Concentration
1 mg/ml
Masse moléculaire
Approximately 39 kDa in PC-3 cell lysate.
Forme du produit
Liquid
Formulation
Supplied in Phosphate Buffered Saline with 0.02% Sodium Azide.
Stockage
Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.
Notes générales
Rabbit anti Human BAG1 antibody recognizes the C-terminal (CT) region of Bcl-2 associated athanogene-1 (BAG1), a co-chaperone protein which binds to and regulates the 70 kDa heat shock proteins (Hsp70/Hsc70). BAG1 has also been shown to interact with the kinase Raf1, a number of steroid and tyrosine kinase receptors, and the Bcl-2 family of proteins. It is thought to function as a molecular switch between cell growth and differentiation, and cell survival. The BAG1 gene encodes three different isoforms; a predominantly cytosolic form of ~36 kDa (BAG1S), a ~46 kDa cytosolic and nuclear form (BAG1M), and a predominantly nuclear form ~50 kD (BAG1L).BAG1 displays potent neuroprotective activity in vivo against stroke, and could be used for reducing brain injury during cerebral ischemia and neurodegenerative diseases (Kermer et al. 2003). BAG1 may also promote chemoresistance, growth factor independence, and anchorage independent cell growth in tumour cells.
Synonymes
Bag 1, BAG family molecular chaperone regulator 1, BAG-1, BAG1_HUMAN, BCL 2 associated athanogene, BCL 2 Associated Athanogene 1, BCL 2 binding athanogene 1, Bcl-2-associated athanogene 1, BCL2 associated athanogene, BCL2 associated athanogene 1, Glucocorticoid receptor-associated protein RAP46, HAP1, Haptoglobin, RAP 46, RAP46
Avertissement
Ce produit est uniquement destiné à la recherche. Il n'est pas destiné à un usage diagnostique ou thérapeutique.

Produits alternatifs à Anti-Bag1 Anticorps (A283041)

Haut