Anti-alpha II Spectrin Anticorps [SPTAN1/3507] (A277812)

Name: Anti-alpha II Spectrin Antibody [SPTAN1/3507]
Brand: Antibodies.com
SKU: A277812
Price: 525.0 USD
Availability: InStock

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$525

Anticorps monoclonal [SPTAN1/3507] de souris contre alpha II Spectrin pour IHC-P.

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Alternative Formats and ConjugatesAlternative Formats

Carrier Free and Preservative Free

Livraison

Frais de livraison

$40

Date de livraison

Livraison sous 4-6 jours ouvrables.

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Téléphone

+1 (314) 370-6046

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orders@antibodies.com

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Mots clés :

Anticorps Monospécifique

Spécifications

Nom du produit

Anti-alpha II Spectrin Antibody [SPTAN1/3507]

Description du produit

Mouse monoclonal [SPTAN1/3507] antibody to alpha II Spectrin.

Spécificité

Spectrin, an actin binding protein that is a major component of the cytoskeletal superstructure of the erythrocyte plasma membrane, is essential in determining the properties of the membrane including its shape and deformability. Spectrins function as membrane organizers and stabilizers, composed of nonhomologous Î± and Î² chains, which aggregate side-to-side in an antiparallel fashion to form dimers, tetramers, and higher polymers. Spectrin Î± I and spectrin Î² I are present in erythrocytes, whereas spectrin Î± II (also designated fodrin Î±) and spectrin Î² II (also designated fodrin Î²) are present in other somatic cells. The spectrin tetramers in erythrocytes act as barriers to lateral diffusion, but spectrin dimers seem to lack this function. Activation of calpain results in the breakdown of spectrin Î± II, a neuronal cytoskeleton protein.

Applications

IHC-P

Recommander des dilutions

IHC-P: 1-2 µg/ml

Reactivité

Human

Immunogène

Recombinant fragment, around amino acids 2,351-2,475, of human alpha II Spectrin. The exact sequence is proprietary.

Hôte

Mouse

Clonalité

Monoclonal

Clone

SPTAN1/3507

Isotype

IgG

Conjuguer

Unconjugated

Purification

Protein A/G chromatography.

Concentration

200 µg/ml

Masse moléculaire

240 kDa

Forme du produit

Liquid

Formulation

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Stockage

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Notes générales

This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-alpha II Spectrin Antibody [SPTAN1/3507] - BSA and Azide free (A278400).

Synonymes

(ALPHA)II-SPECTRIN, Alpha Fodrin, Alpha-II spectrin, brain, EIEE5, FLJ17738, FLJ44613, Fodrin alpha chain, Fodrin, alpha, NEAS, Non erythrocytic spectrin alpha, non-erythroid alpha chain, SPECA, Spectrin, Spectrin alpha chain, Spectrin alpha chain brain, Spectrin alpha non erythrocytic 1, Spectrin non erythroid alpha chain, Spectrin, alpha, non-erythrocytic 1 (alpha-fodrin), Spectrin, nonerythroid, alpha subunit, Spna2, SPTA 2, SPTA2, SPTA2_HUMAN, SPTAN 1, SPTAN1

Contrôles isotype

Mouse IgG (A17361)

Anticorps secondaires appropriés

Avertissement

Ce produit est uniquement destiné à la recherche. Il n'est pas destiné à un usage diagnostique ou thérapeutique.

Images (4)

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Figure 1: Immunohistochemistry - Anti-alpha II Spectrin Antibody [SPTAN1/3507] (A277812)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded human placenta tissue using Anti-alpha II Spectrin Antibody [SPTAN1/3507].

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Figure 2: Immunohistochemistry - Anti-alpha II Spectrin Antibody [SPTAN1/3507] (A277812)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded human placenta tissue using Anti-alpha II Spectrin Antibody [SPTAN1/3507].

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Figure 3: SDS-PAGE - Anti-alpha II Spectrin Antibody [SPTAN1/3507] (A277812)

SDS-PAGE analysis of Anti-alpha II Spectrin Antibody [SPTAN1/3507] under non-reduced and reduced conditions; showing intact IgG and intact heavy and light chains, respectively. SDS-PAGE analysis confirms the integrity and purity of the antibody.

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Figure 4: Anti-alpha II Spectrin Antibody [SPTAN1/3507] (A277812)

Analysis of protein array containing more than 19,000 full-length human proteins using Anti-alpha II Spectrin Antibody [SPTAN1/3507]. Z-Score and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProt^TM array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If targets on HuProt^TM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target; a MAb is considered to be specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.