Anti-ALK Anticorps [ALK/1504] (A248625)

Anticorps monoclonal [ALK/1504] de souris contre ALK pour IHC-P.

Alternative Formats and ConjugatesAlternative Formats

Frais de livraison
Date de livraison
Livraison sous 4-6 jours ouvrables.
Téléphone
+1 (314) 370-6046
Lun - Ven, 8h - 16h AST
E-mail
orders@antibodies.com
Nom du produit
Anti-ALK Antibody [ALK/1504]
Description du produit
Mouse monoclonal [ALK/1504] antibody to ALK.
Spécificité
The wild-type anaplastic lymphoma kinase (ALK) protein is a 200kDa transmembrane receptor tyrosine kinase. Its expression is restricted to a few scattered cells in the nervous system (some glial cells and neurons, and a few endothelial cells and pericytes. The hybrid gene,NPM-ALK, created by the t(2;5)(p23;q35) chromosomal translocation encodes part of the nucleolar phosphoprotein, nucleophosmin (NPM), joined to the entire cytoplasmic portion of the anaplastic lymphoma kinase (ALK) receptor tyrosine kinase. As a consequence, the ALK gene comes under the control of the NPM promoter, which induces a permanent and ubiquitous transcription of the NPM-ALK hybrid gene, resulting in the production of a 80kDa NPM-ALK chimeric protein. This translocation is found in anaplastic large cell lymphomas (ALCL). Reportedly, expression of ALK indicates a better prognosis. Approximately 5%-10% of non-small cell lung carcinomas also express ALK protein producing a cytoplasmic staining pattern. This MAb also reacts with blood vessels that serves as an internal positive control.
Applications
IHC-P
Recommander des dilutions
IHC-P: 1-2 µg/ml
Reactivité
Human
Immunogène
Recombinant fragment, around amino acids 200-335, of human ALK protein. The exact sequence is proprietary.
Hôte
Mouse
Clonalité
Monoclonal
Clone
ALK/1504
Isotype
IgG2b
Chaînes légères
kappa
Conjuguer

Unconjugated

Purification
Protein A/G chromatography.
Concentration
200 µg/ml
Masse moléculaire
80 kDa (hybrid) / 200 kDa (wild type)
Forme du produit
Liquid
Formulation
Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.
Stockage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Notes générales
This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-ALK Antibody [ALK/1504] - BSA and Azide free (A251807).
Synonymes
ALK tyrosine kinase receptor, ALK/EML4 fusion gene, included, ALK/NPM1 fusion gene, included, ALK_HUMAN, Anaplastic lymphoma kinase, anaplastic lymphoma kinase (Ki-1), Anaplastic lymphoma kinase Ki1, anaplastic lymphoma receptor tyrosine kinase, CD 246, CD246, CD246 antigen, EC 2.7.10.1, Ki 1, Ki1, mutant anaplastic lymphoma kinase, NBLST 3, NBLST3, Tcrz, TFG/ALK
Avertissement
Ce produit est uniquement destiné à la recherche. Il n'est pas destiné à un usage diagnostique ou thérapeutique.

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